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Cost-effectiveness of Strategies to Identify Children with Perinatally Acquired Hepatitis C Infection
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7 2023
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Source: J Pediatr. 258:113409
[PDF-819.25 KB]
Details:
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Alternative Title:J Pediatr
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Description:Objectives:
We aimed to determine the optimal testing strategy to identify children with perinatally acquired hepatitis C virus (HCV) infection.
Study Design:
We used a decision-tree framework with a Markov disease progression model to conduct an economic analysis of four strategies, based on combinations of type and timing of test: Anti-HCV with reflex to HCV RNA at 18 months among children known to be perinatally exposed (ie, baseline comparison strategy); HCV RNA testing at 2–6 months among infants known to be perinatally exposed (Test Strategy 1); universal anti-HCV with reflex to HCV RNA at 18 months among all children (Test Strategy 2); universal HCV RNA testing at 2–6 months among all infants (Test Strategy 3). We estimated total cost, quality-adjusted life years (QALYs), and disease sequalae for each strategy.
Results:
Each of the three alternative testing strategies resulted in an increased number of children tested and improved health outcomes. HCV RNA testing at 2–6 months (Test Strategy 1) was cost-saving and resulted in a population-level difference in cost of $469,671. The two universal testing strategies resulted in an increase in QALYs and an increase in total costs.
Conclusions:
Testing of perinatally exposed infants at age 2–6 months with a single HCV RNA test will reduce costs and improve health outcomes, preventing morbidity and mortality associated with complications from perinatal HCV infections.
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Pubmed ID:37023948
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Pubmed Central ID:PMC10448738
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Volume:258
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