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Cost-effectiveness of HPV vaccination for adults through age 45 years in the United States: Estimates from a simplified transmission model
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11 25 2020
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Source: Vaccine. 38(50):8032-8039
Details:
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Alternative Title:Vaccine
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Personal Author:
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Description:Introduction:
The objective of this study was to assess incremental costs and benefits of a human papillomavirus (HPV) vaccination program expanded to include “mid-adults” (adults aged 27 through 45 years) in the United States.
Methods:
We adapted a previously published, dynamic mathematical model of HPV transmission and HPV-associated disease to estimate the incremental costs and benefits of a 9vHPV program for people aged 12 through 45 years compared to a 9vHPV program for females aged 12 through 26 years and males aged 12 through 21 years.
Results:
A 9vHPV program for females aged 12 through 26 years and males aged 12 through 21 years was estimated to cost < $10,000 quality-adjusted life year (QALY) gained, compared to no vaccination. Expanding the 9vHPV program to include mid-adults was estimated to cost $587,600 per additional QALY gained when including adults through age 30 years, and $653,300 per additional QALY gained when including adults through age 45 years. Results were most sensitive to assumptions about HPV incidence among mid-adults, current and historical vaccination coverage, vaccine price, and the impact of HPV diseases on quality of life.
Conclusions:
Mid-adult vaccination is much less cost-effective than the comparison strategy of routine vaccination for all adolescents at ages 11 to 12 years and catch-up vaccination for women through age 26 years and all men through age 21 years.
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Subjects:
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Source:
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Pubmed ID:33121846
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Pubmed Central ID:PMC10395540
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Document Type:
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Funding:
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Volume:38
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Issue:50
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Download URL:
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File Type:
[PDF-658.15 KB]
