Cost-effectiveness of HPV vaccination for adults through age 45 years in the United States: Estimates from a simplified transmission model

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Chesson, Harrell W. ; Meites, Elissa ; Ekwueme, Donatus U. ; Saraiya, Mona ; Markowitz, Lauri E.
• Description:
  Introduction: ; The objective of this study was to assess incremental costs and benefits of a human papillomavirus (HPV) vaccination program expanded to include “mid-adults” (adults aged 27 through 45 years) in the United States. ; Methods: ; We adapted a previously published, dynamic mathematical model of HPV transmission and HPV-associated disease to estimate the incremental costs and benefits of a 9vHPV program for people aged 12 through 45 years compared to a 9vHPV program for females aged 12 through 26 years and males aged 12 through 21 years. ; Results: ; A 9vHPV program for females aged 12 through 26 years and males aged 12 through 21 years was estimated to cost < $10,000 quality-adjusted life year (QALY) gained, compared to no vaccination. Expanding the 9vHPV program to include mid-adults was estimated to cost $587,600 per additional QALY gained when including adults through age 30 years, and $653,300 per additional QALY gained when including adults through age 45 years. Results were most sensitive to assumptions about HPV incidence among mid-adults, current and historical vaccination coverage, vaccine price, and the impact of HPV diseases on quality of life. ; Conclusions: ; Mid-adult vaccination is much less cost-effective than the comparison strategy of routine vaccination for all adolescents at ages 11 to 12 years and catch-up vaccination for women through age 26 years and all men through age 21 years.
• Subjects:
  • Adolescent
  • Adult
  • Child
  • Cost-Benefit Analysis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Papillomavirus Infections
  • Papillomavirus Vaccines
  More +
• Source:
  Vaccine. 38(50):8032-8039
• Pubmed ID:
  33121846
• Pubmed Central ID:
  PMC10395540
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  38
• Issue:
  50
• Download URL:
  https://stacks.cdc.gov/view/cdc/131723/cdc_131723_DS1.pdf
• File Type:
  [PDF - 658.15 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1550a164b4d2a916e8c30f548888dce074f6b8a555209e4c9d9c470bee124587