Efficacy of inactivated poliovirus vaccine in India

Details

• Alternative Title:
  Science
• Personal Author:
  Jafari, Hamid ; Deshpande, Jagadish M. ; Sutter, Roland W. ; Bahl, Sunil ; Verma, Harish ; Ahmad, Mohammad ; Kunwar, Abhishek ; Vishwakarma, Rakesh ; Agarwal, Ashutosh ; Jain, Shilpi ; Estivariz, Concepcion ; Sethi, Raman ; Molodecky, Natalie A. ; Grassly, Nicholas C. ; Pallansch, Mark A. ; Chatterjee, Arani ; Aylward, R. Bruce
• Description:
  Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV in boosting mucosal immunity. Participants received IPV, bivalent 1 and 3 oral poliovirus vaccine (bOPV), or no vaccine. A bOPV challenge was administered 4 weeks later, and excretion was assessed 3, 7, and 14 days later. Nine hundred and fifty-four participants completed the study. Any fecal shedding of poliovirus type 1 was 8.8, 9.1, and 13.5% in the IPV group and 14.4, 24.1, and 52.4% in the control group by 6- to 11-month, 5-year, and 10-year groups, respectively (IPV versus control: Fisher's exact test P < 0.001). IPV reduced excretion for poliovirus types 1 and 3 between 38.9 and 74.2% and 52.8 and 75.7%, respectively. Thus, IPV in OPV-vaccinated individuals boosts intestinal mucosal immunity.
• Subjects:
  Adult Antibodies, Viral Child Child, Preschool Disease Eradication Feces Female Humans Immunity, Mucosal Immunization, Secondary Infant Intestinal Mucosa Male Middle Aged Poliomyelitis Poliovirus Poliovirus Vaccine, Inactivated Poliovirus Vaccine, Oral Prevalence Virus Shedding

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• Source:
  Science. 345(6199):922-925
• Pubmed ID:
  25146288
• Pubmed Central ID:
  PMC10389671
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; MR/K010174/1/MRC_/Medical Research CouncilUnited Kingdom/
• Place as Subject:
  India
• Volume:
  345
• Issue:
  6199
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6ff2cc2ec45c3498b97ced7ea706f881acc959c5689b7de5cb1e40b4e762532e
• Download URL:
  https://stacks.cdc.gov/view/cdc/131545/cdc_131545_DS1.pdf
• File Type:
  [PDF - 320.56 KB ]