Validation of a diphtheria toxoid multiplex bead assay for serosurveys

Scobie, Heather M.; Khetsuriani, Nino; Efstratiou, Androulla; Priest, Jeffrey W.

doi:10.1016/j.diagmicrobio.2021.115371

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Validation of a diphtheria toxoid multiplex bead assay for serosurveys

7 2021
By Scobie, Heather M. ; Khetsuriani, Nino ; Efstratiou, Androulla ; ...
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115371
Source: Diagn Microbiol Infect Dis. 100(3):115371

[PDF-271.74 KB]

English

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Details:

Alternative Title:

Diagn Microbiol Infect Dis
Personal Author:

Scobie, Heather M. ; Khetsuriani, Nino ; Efstratiou, Androulla ; Priest, Jeffrey W.

Scobie, Heather M. ; Khetsuriani, Nino ; Efstratiou, Androulla ; Priest, Jeffrey W. Less -
Description:

We validated a multiplex bead assay for diphtheria toxoid IgG antibodies against the Vero cell toxin neutralization test using 1300 specimens (correlation = 0.88). At the ≥0.01 IU/mL cutoff for minimal seroprotection, sensitivity was 95% and specificity was 83%. Agreement for three categories (<0.01, 0.01-<0.1, ≥0.1 IU/mL) was 81% (kappa = 0.71).
Subjects:

[+]

Animals Antibodies, Bacterial Chlorocebus Aethiops Diphtheria Toxoid Immunoglobulin G Neutralization Tests Reproducibility Of Results Sensitivity And Specificity Serologic Tests Vero Cells
Source:

Diagn Microbiol Infect Dis. 100(3):115371
Pubmed ID:

33838594
Pubmed Central ID:

PMC10370405
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

100
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:91c01c69b67b0ef9478dc1296c5c97e1c33101adf32f430ef3c438b10961d77e
Download URL:

https://stacks.cdc.gov/view/cdc/131472/cdc_131472_DS1.pdf
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	nihms-1912905-f0001.jpg	jpeg
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	NIHMS1912905-supplement-1.pdf	pdf

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