Association of Culturable-Virus Detection and Household Transmission of SARS-CoV-2, California and Tennessee, 2020–2022

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Deyoe, Jessica E. ; Kelly, J. Daniel ; Grijalva, Carlos G. ; Bonenfant, Gaston ; Lu, Scott ; Anglin, Khamal ; Garcia-Knight, Miguel ; Pineda-Ramirez, Jesus ; Hagen, Melissa Briggs ; Saydah, Sharon ; Abedi, Glen R. ; Goldberg, Sarah A. ; Tassetto, Michel ; Zhang, Amethyst ; Donohue, Kevin C. ; Davidson, Michelle C. ; Sanchez, Ruth Diaz ; Djomaleu, Manuella ; Mathur, Sujata ; Shak, Joshua R. ; Deeks, Steven G. ; Peluso, Michael J. ; Chiu, Charles Y. ; Zhu, Yuwei ; Halasa, Natasha B. ; Chappell, James D. ; Mellis, Alexandra ; Reed, Carrie ; Andino, Raul ; Martin, Jeffrey N. ; Zhou, Bin ; Talbot, H. Keipp ; Midgley, Claire M. ; Rolfes, Melissa A.
• Description:
  From 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission studies (enrolling April 2020 to January 2022) with rapid enrollment and specimen collection for 14 days, 61% (43/70) of primary cases had culturable virus detected ≥6 days post-onset. Risk of secondary infection among household contacts tended to be greater when primary cases had culturable virus detected after onset. Regardless of duration of culturable virus, most secondary infections (70%, 28/40) had serial intervals <6 days, suggesting early transmission. These data examine viral culture as a proxy for infectiousness, reaffirm the need for rapid control measures after infection, and highlight the potential for prolonged infectiousness (≥6 days) in many individuals.
• Subjects:
  California COVID-19 Family Characteristics Humans SARS-CoV-2 Tennessee
• Keywords:
  Household Transmission Secondary Infection Risk Viral Culture
• Source:
  J Infect Dis. 227(12):1343-1347
• Pubmed ID:
  36705269
• Pubmed Central ID:
  PMC10266938
• Document Type:
  Journal Article
• Funding:
  K23 AI157875/AI/NIAID NIH HHSUnited States/ ; K24 AI148459/AI/NIAID NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; UL1 TR002243/TR/NCATS NIH HHSUnited States/ ; U01 IP001083/IP/NCIRD CDC HHSUnited States/ ; L30 AI147159/AI/NIAID NIH HHSUnited States/ ; L30 AI126521/AI/NIAID NIH HHSUnited States/ ; K23 AI146268/AI/NIAID NIH HHSUnited States/
• Volume:
  227
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:26ad7ad7a478b0e78989e327c263020cba064dcb0b0d6411af34dd495be48b7704b21fe0394bbb909db5ae13f79f5ab48e08cc8440b022dd5f870e543c723ee6
• Download URL:
  https://stacks.cdc.gov/view/cdc/130701/cdc_130701_DS1.pdf
• File Type:
  [PDF - 240.24 KB ]