Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome

Kaufmann, Walter E.; Raspa, Melissa; Bann, Carla M.; Gable, Julia M.; Harris, Holly K.; Budimirovic, Dejan B.; Lozano, Reymundo

doi:10.1007/s10803-022-05821-7

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Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome

2 2024
By Kaufmann, Walter E. ; Raspa, Melissa ; Bann, Carla M. ; ...
Source: J Autism Dev Disord. 54(2):725-737

Public Access Version Available on: February 01, 2025, 12:00 AM

Please check back on the date listed above.

English

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Alternative Title:

J Autism Dev Disord
Personal Author:

Kaufmann, Walter E. ; Raspa, Melissa ; Bann, Carla M. ; Gable, Julia M. ; Harris, Holly K. ; ... More +

Kaufmann, Walter E. ; Raspa, Melissa ; Bann, Carla M. ; Gable, Julia M. ; Harris, Holly K. ; Budimirovic, Dejan B. ; Lozano, Reymundo Less -
Description:

Fragile X syndrome (FXS) is characterized by variable neurobehavioral abnormalities, which leads to difficulties in developing and evaluating treatments and in determining accurate prognosis. We employed a pediatric cross-sectional sample (1,072 males, 338 females) from FORWARD, a clinic-based natural history study, to identify behavioral subtypes by latent class analysis. Input included co-occurring behavioral conditions, sleep and sensory problems, autistic behavior scales (SCQ, SRS-2), and the Aberrant Behavior Checklist revised for FXS (ABC|). A 5-class solution yielded the most clinically meaningful, pharmacotherapy independent behavioral groups with distinctive SCQ, SRS-2, and ABC| profiles, and adequate non-overlap (≥ 71%): "Mild" (31%), "Moderate without Social Impairment" (32%), "Moderate with Social Impairment" (7%), "Moderate with Disruptive Behavior" (20%), and "Severe" (9%). Our findings support FXS subtyping, for improving clinical management and therapeutic development.
Subjects:

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Autism Spectrum Disorder Child Cross-Sectional Studies Female Fragile X Syndrome Humans Latent Class Analysis Male Social Behavior
Keywords:

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Autism Symptomatology Fragile X Syndrome Intellectual Disability Latent Class Analysis Maladaptive Behavior Phenotypes
Source:

J Autism Dev Disord. 54(2):725-737
Pubmed ID:

36441429
Pubmed Central ID:

PMC10258834
Document Type:

Journal Article
Funding:

U01DD001189/ACL/ACL HHSUnited States/ ; U01 DD000231/DD/NCBDD CDC HHSUnited States/ ; U19 DD000753/DD/NCBDD CDC HHSUnited States/ ; #U19DD000753/DD/NCBDD CDC HHSUnited States/ ; K01 NS126736/NS/NINDS NIH HHSUnited States/ ; ... More +

U01DD001189/ACL/ACL HHSUnited States/ ; U01 DD000231/DD/NCBDD CDC HHSUnited States/ ; U19 DD000753/DD/NCBDD CDC HHSUnited States/ ; #U19DD000753/DD/NCBDD CDC HHSUnited States/ ; K01 NS126736/NS/NINDS NIH HHSUnited States/ ; contract 75D30120F09737/DD/NCBDD CDC HHSUnited States/ ; # U01DD001189/DD/NCBDD CDC HHSUnited States/ ; U01 DD001189/DD/NCBDD CDC HHSUnited States/ ; U01DD000231/DD/NCBDD CDC HHSUnited States/ Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:887faffd959a21cc144507124242db91debcaac70a08d23d1a07de8c1da6f07a
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