Dihydroartemisinin–piperaquine treatment failure in uncomplicated Plasmodium falciparum malaria case imported from Ethiopia

Russo, Gianluca; L’Episcopia, Mariangela; Menegon, Michela; Souza, Samaly Santos; Dongho, Bruna Ghyslaine Djeunang; Vullo, Vincenzo; Lucchi, Naomi W.; Severini, Carlo

doi:10.1007/s15010-018-1174-9

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Dihydroartemisinin–piperaquine treatment failure in uncomplicated Plasmodium falciparum malaria case imported from Ethiopia

12 2018
By Russo, Gianluca ; L’Episcopia, Mariangela ; Menegon, Michela ; ...
http://dx.doi.org/10.1007/s15010-018-1174-9
Source: Infection. 46(6):867-870

[PDF-326.51 KB]

English

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Details:

Alternative Title:

Infection
Personal Author:

Russo, Gianluca ; L’Episcopia, Mariangela ; Menegon, Michela ; Souza, Samaly Santos ; Dongho, Bruna Ghyslaine Djeunang ; ... More +

Russo, Gianluca ; L’Episcopia, Mariangela ; Menegon, Michela ; Souza, Samaly Santos ; Dongho, Bruna Ghyslaine Djeunang ; Vullo, Vincenzo ; Lucchi, Naomi W. ; Severini, Carlo Less -
Description:

Dihydroartemisinin-piperaquine (DHA-PPQ) is the artemisinin combination therapy that was recently introduced for the treatment of Plasmodium falciparum uncomplicated malaria, but emerging resistance in South-East Asia is threatening its use. This report describes a case of DHA-PPQ treatment failure in uncomplicated malaria occurring in an immigrant living in Italy, after a travel to Ethiopia. Thirty days after malaria recovery following DHA-PPQ therapy, the patient had malaria recrudescence. According to the genotyping analysis, the same P. falciparum was responsible for both episodes. Thus, it seems important to consider possible malaria recrudescence occurring after DHA-PPQ therapy in patients from African countries.
Subjects:

[+]

Adult Artemisinins Article Communicable Diseases, Imported Dihydroartemisinin Drug Combinations Ethiopia Failure Female Humans Italy Malaria, Falciparum Malaria Recrudescence Piperaquine Quinolines Treatment Failure
Source:

Infection. 46(6):867-870
Pubmed ID:

29980936
Pubmed Central ID:

PMC10235439
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Place as Subject:

Ethiopia
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:974ed42b3213bced04b7f9c9f5218739865349b4458d2abb36428a6cfc98845d
Download URL:

https://stacks.cdc.gov/view/cdc/129385/cdc_129385_DS1.pdf
File Type:

nihms-1896814.nxml

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