Profiles and Predictors of Environmental Chemical Mixture Exposure among Pregnant Women: The Health Outcomes and Measures of the Environment Study

Details

• Alternative Title:
  Environ Sci Technol
• Personal Author:
  Kalloo, Geetika ; Wellenius, Gregory A. ; McCandless, Lawrence ; Calafat, Antonia M. ; Sjodin, Andreas ; Karagas, Margaret ; Chen, Aimin ; Yolton, Kimberly ; Lanphear, Bruce P. ; Braun, Joseph M.
• Description:
  Pregnant women are exposed to numerous environmental chemicals, but there is limited understanding of chemical mixture exposure profiles and predictors. In a prospective cohort of 389 pregnant women from Cincinnati, OH, we used biomarkers to estimate exposure to 41 phenols, phthalates, metals, organophosphate/pyrethroid/organochlorine pesticides, polychlorinated biphenyls, polybrominated diphenyl ethers, perfluoroalkyl substances, and environmental tobacco smoke. Using pairwise correlations, k-means clustering, and principal component analysis (PCA), we identified several profiles of chemical exposure. Chemicals within structurally, commercially, or industrially related chemical classes (e.g., phthalates) were moderate to strongly correlated compared to unrelated chemicals (e.g., pyrethroid pesticides and environmental tobacco smoke). Using k-means clustering and PCA, we identified 3 clusters of women ( N = 106, 158, and 125) and 6 PC scores, respectively, that characterized profiles of cumulative chemical exposure. The first two PC scores significantly varied by cluster, indicating that some of these profiles could be identified using both methods. Cluster membership and PCA scores were associated with race, marital status, consumption of fresh fruits and vegetables, and parity. Future work could use clusters and PCA scores to characterize environmental chemical mixture exposures in other cohorts of pregnant women and predict potential health effects of environmental chemical mixture exposure.
• Subjects:
  Environmental Exposure Environmental Pollutants Female Humans Hydrocarbons, Chlorinated Pesticides Polychlorinated Biphenyls Pregnancy Prospective Studies
• Source:
  Environ Sci Technol. 52(17):10104-10113
• Pubmed ID:
  30088764
• Pubmed Central ID:
  PMC10105973
• Document Type:
  Journal Article
• Funding:
  R01 ES021357/ES/NIEHS NIH HHSUnited States/ ; P01 ES011261/ES/NIEHS NIH HHSUnited States/ ; P30 ES006096/ES/NIEHS NIH HHSUnited States/ ; R01 ES014575/ES/NIEHS NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 ES024381/ES/NIEHS NIH HHSUnited States/ ; R01 ES015517/ES/NIEHS NIH HHSUnited States/ ; R01 ES025214/ES/NIEHS NIH HHSUnited States/ ; R01 ES020349/ES/NIEHS NIH HHSUnited States/
• Volume:
  52
• Issue:
  17
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e2785ae893f325e5a6d2c1652f69be22bbd493a20d85f7f6405c58cc5f7f0f0d
• Download URL:
  https://stacks.cdc.gov/view/cdc/127267/cdc_127267_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]