Epidemiology of Cutaneous Lupus Erythematosus Among Adults Over Four Decades (1976–2018): A Lupus Midwest Network (LUMEN) Study

Details

• Alternative Title:
  Mayo Clin Proc
• Personal Author:
  Hocaoğlu, Mehmet ; Davis, Mark Denis P. ; Osei-Onomah, Shirley-Ann ; Valenzuela-Almada, Maria O. ; Dabit, Jesse Y. ; Duong, Stephanie Q. ; Yang, Jeffrey X. ; Helmick, Charles G. ; Crowson, Cynthia ; Duarte-García, Alí
• Description:
  Objective:
  
  To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota.
  
  Patients and Methods:
  
  In this retrospective population-based cohort study, all incident and prevalent CLE cases among adult residents in Olmsted County, Minnesota, between January 1, 1976, and December 31, 2018, were identified and categorized by subtype through medical record review using the resources of the Rochester Epidemiology Project.
  
  Results:
  
  The overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5) per 100,000. The incidence of CLE was relatively stable, with no major trend across sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000 on January 1, 2015. Mortality in CLE patients was similar to that of the general population, with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed trends in mortality over time.
  
  Conclusion:
  
  In the past 4 decades, the incidence of CLE remained stable. Patients with CLE have mortality comparable to that of the general population.
  
  
• Keywords:
  Adult Cohort Studies Humans Incidence Lupus Erythematosus, Cutaneous Minnesota Prevalence Retrospective Studies
• Source:
  Mayo Clin Proc. 97(12):2282-2290
• Pubmed ID:
  36347648
• Pubmed Central ID:
  PMC10013735
• Document Type:
  Journal Article
• Funding:
  U01DP006491/ACL/ACL HHSUnited States/ ; UL1 TR002377/TR/NCATS NIH HHSUnited States/ ; R01 AG034676/AG/NIA NIH HHSUnited States/ ; U01 DP006491/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP006703/DP/NCCDPHP CDC HHSUnited States/ ; R33 AG058738/AG/NIA NIH HHSUnited States/
• Volume:
  97
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:27627e4adee645cfd2b4182f03d6cc25462824d4ec2aecde700ebdc4c6ce0150
• Download URL:
  https://stacks.cdc.gov/view/cdc/125737/cdc_125737_DS1.pdf
• File Type:
  [PDF - 709.40 KB ]