Increase in Extensively Drug-Resistant Shigellosis in the United States [February 24, 2023, 11:30 AM ET]

Details

• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.). Health Alert Network (HAN)
• Description:
  February 24, 2023, 11:30 AM ET
  
  CDCHAN-00486
  
  The Centers for Disease Control and Prevention (CDC) has been monitoring an increase in extensively drug-resistant (XDR) Shigella infections (shigellosis) reported through national surveillance systems [1]. In 2022, about 5% of Shigella infections reported to CDC were caused by XDR strains, compared with 0% in 2015. Clinicians treating patients infected with XDR strains have limited antimicrobial treatment options. Shigella bacteria are easily transmissible. XDR Shigella strains can spread antimicrobial resistance genes to other enteric bacteria. Given these potentially serious public health concerns, CDC asks healthcare professionals to be vigilant about suspecting and reporting cases of XDR Shigella infection to their local or state health department and educating patients and communities at increased risk about prevention and transmission.
  
  Shigellosis is an acute enteric infection that is an important cause of domestically acquired and travel-associated bacterial diarrhea in the United States. Shigellosis usually causes inflammatory diarrhea that can be bloody and may also lead to fever, abdominal cramping, and tenesmus. Infections are generally self-limiting; however, antimicrobial treatment may be indicated to prevent complications or shorten the duration of illness [2]. CDC defines XDR Shigella bacteria as strains that are resistant to all commonly recommended empiric and alternative antibiotics — azithromycin, ciprofloxacin, ceftriaxone, trimethoprim-sulfamethoxazole (TMP-SMX), and ampicillin. Currently, there are no data from clinical studies of treatment of XDR Shigella to inform recommendations for the optimal antimicrobial treatment of these infections. As such, CDC does not have recommendations for optimal antimicrobial treatment of XDR Shigella infections.
  
  
• Content Notes:
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  Health Alert: Requires immediate action or attention, highest level of importance.
  
  Health Advisory: May not require immediate action; provides important information for a specific incident or situation.
  
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• Subjects:
  Drug Resistance, Multiple, Bacterial Dysentery, Bacillary Foodborne Diseases Sexually Transmitted Diseases, Bacterial Shigella Sonnei
• Keywords:
  HAN Health Alert Network
• Source:
  HAN ; 486
• Series:
  Health Alert Network
• Subseries:
  CDC Health Advisory
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Document Type:
  Text
• Genre:
  Alert
• Place as Subject:
  United States
• Rights:
  Public Domain
• Issue:
  00486
• Collection(s):
  Health Alert Network (HAN)
• Main Document Checksum:
  urn:sha-512:5c7bebd3942a9452bfc88fc7915c4787aff04f7102f2e18773863e1e269ecf99fe081c898b4e7f7f8ff60824b906c606141d1fa67768f0e20f2eed413f80b4f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/125179/cdc_125179_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]