Traffic-Related Air Pollution, Biomarkers of Metabolic Dysfunction, Oxidative Stress, and CC16 in Children

Zhang, Amy L.; Balmes, John R.; Lutzker, Liza; Mann, Jennifer K.; Margolis, Helene G.; Tyner, Tim; Holland, Nina; Noth, Elizabeth M.; Lurmann, Fred; Hammond, S. Katharine; Holm, Stephanie M.

doi:10.1038/s41370-021-00378-6

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Traffic-Related Air Pollution, Biomarkers of Metabolic Dysfunction, Oxidative Stress, and CC16 in Children

2022
By Zhang, Amy L. ; Balmes, John R. ; Lutzker, Liza ; ...
http://dx.doi.org/10.1038/s41370-021-00378-6
Source: J Expo Sci Environ Epidemiol. 32(4):530-537

[PDF-652.63 KB]

English

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Details:

Alternative Title:

J Expo Sci Environ Epidemiol
Personal Author:

Zhang, Amy L. ; Balmes, John R. ; Lutzker, Liza ; Mann, Jennifer K. ; Margolis, Helene G. ; ... More +

Zhang, Amy L. ; Balmes, John R. ; Lutzker, Liza ; Mann, Jennifer K. ; Margolis, Helene G. ; Tyner, Tim ; Holland, Nina ; Noth, Elizabeth M. ; Lurmann, Fred ; Hammond, S. Katharine ; Holm, Stephanie M. Less -
Description:

Background:

Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children.

Objective:

This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children.

Methods:

We conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n=218) to examine associations between air pollutants (nitrogen dioxide (NO2), nitrogen oxides (NOx), elemental carbon (EC), polycyclic aromatic hydrocarbons (PAH), carbon monoxide (CO), fine particulates (PM2.5)) and biomarkers of metabolic function (high density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)).

Results:

HDL cholesterol showed an inverse association with NO2 and NOx, with the strongest relationship between HDL and 3-month exposure to NO2 (−15.4 mg/dL per IQR increase in 3-month NO2, 95% CI = −27.4, −3.4). 8-isoprostane showed a consistent pattern of increasing values with 1-day and 1-week exposure across all pollutants. Non-significant increases in % HbA1c were found during 1-month time frames and decreasing CC16 in 3-month exposure time frames.

Conclusion:

Our results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood.
Subjects:

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Air Pollutants Air Pollution Biomarkers Child Cholesterol, HDL Cross-Sectional Studies Environmental Exposure Glycated Hemoglobin Humans Nitrogen Dioxide Oxidative Stress Particulate Matter Uteroglobin Vehicle Emissions
Source:

J Expo Sci Environ Epidemiol. 32(4):530-537
Pubmed ID:

34417545
Pubmed Central ID:

PMC8858324
Document Type:

Journal Article
Funding:

P01 ES022849/ES/NIEHS NIH HHSUnited States/ ; R24 ES030888/ES/NIEHS NIH HHSUnited States/ ; R33 ES024719/ES/NIEHS NIH HHSUnited States/ ; T42 OH008429/OH/NIOSH CDC HHSUnited States/

P01 ES022849/ES/NIEHS NIH HHSUnited States/ ; R24 ES030888/ES/NIEHS NIH HHSUnited States/ ; R33 ES024719/ES/NIEHS NIH HHSUnited States/ ; T42 OH008429/OH/NIOSH CDC HHSUnited States/ Less -
Volume:

32
Issue:

4
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:fda22d95420663cbd5834bd54d8c2d47aa9bec585866d7aa5913889384c685f16d9998486e34eb1c6acbff72a4d8d3796ccccc92c59bd55d56fbcd2f1e307329
Download URL:

https://stacks.cdc.gov/view/cdc/124932/cdc_124932_DS1.pdf
File Type:

	nihms-1730356-f0001.gif	gif
	nihms-1730356-f0001.jpg	jpeg
	nihms-1730356.nxml	xml
	NIHMS1730356-supplement-1.pdf	pdf

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