Rapid determination of thorium in urine by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS)

Details

• Alternative Title:
  J Radioanal Nucl Chem
• Personal Author:
  Liu, Yongzhong ; Xiao, Ge ; Jones, Robert L.
• Description:
  Inductively coupled plasma mass spectrometry (ICP-MS) has proven to be an excellent analytical technique with high sensitivity for detecting low levels of long-lived radionuclides, such as thorium. However, the high-sensitivity technique increases the memory effect of thorium. This study developed a rapid, high-throughput, simple method for measuring thorium in urine using quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS). Replacing the commonly used hazardous hydrofluoric acid with a rinse solution of 0.025 mol/L oxalic acid and 5% (v/v) nitric acid eliminated the memory effect of thorium. |U was used as internal standard in this study. The limit of detection (LOD) for thorium in this study is 0.77 ng/L, which is comparable to those of reported methods using more sophisticated and expensive sector field inductively coupled plasma mass spectrometry (SF-ICP-MS). This proposed method can determine thorium concentrations in urine in both occupationally exposed workers and populations that live in areas with high background levels of thorium.
• Subjects:
  Article Limit Of Detection (LOD) Quadrupole Inductively Coupled Plasma Mass Spectrometry (Q-ICP-MS) Sector Field Inductively Coupled Plasma Mass Spectrometry (SF-ICP-MS) Thorium Urine
• Source:
  J Radioanal Nucl Chem. 331(9):3957-3964
• Pubmed ID:
  36744001
• Pubmed Central ID:
  PMC9891388
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  331
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9d39fa6d21e9ce11217b8f13ccac5a616f1830d05d708092155ec131bfc84222
• Download URL:
  https://stacks.cdc.gov/view/cdc/124413/cdc_124413_DS1.pdf
• File Type:
  [PDF - 926.04 KB ]