Details:

Alternative Title:
Environ Pollut
Publisher's site:
http://dx.doi.org/10.1016/j.envpol.2022.120740
Personal Author:
Wang, Xin ; Ding, Ning ; Harlow, Siobán D. ; Randolph, John F. ; Mukherjee, Bhramar ; ... More +
Wang, Xin ; Ding, Ning ; Harlow, Siobán D. ; Randolph, John F. ; Mukherjee, Bhramar ; Gold, Ellen B. ; Park, Sung Kyun Less -
Description:
Exposure to heavy metals may alter the circulating levels of sex hormones. However, epidemiologic studies on heavy metals and sex hormones have been limited, and results have been inconsistent. We assessed the associations of heavy metals assayed in urine, including arsenic, cadmium, lead, and mercury, with repeated measures of serum estradiol (E|), follicle-stimulating hormone (FSH), testosterone, and sex hormone-binding globulin (SHBG) levels in the Study of Women's Health Across the Nation Multi-Pollutant Study. The sample included 1355 White, Black, Chinese, and Japanese women, aged 45-56 years at baseline (1999-2000), whose serum hormone levels were repeatedly measured through 2017. Urinary metal concentrations were measured at baseline. Linear mixed effect models were used to calculate percent changes in serum hormone levels per doubling of urinary metal concentrations, adjusting for demographics, socioeconomic status, lifestyle, health-related factors, and urinary creatinine. After multivariable adjustment, a doubling of urinary metal concentration was associated with lower E| levels by 2.2% (95% CI: 4.0%, -0.3%) for mercury and 3.6% (95% CI: 5.7%, -1.6%) for lead; higher FSH levels by 3.4% (95% CI: 0.9%, 5.9%) for lead; and higher SHBG levels by 3.6% (95% CI: 1.3%, 5.9%) for cadmium. The overall joint effect using the Bayesian kernel machine regression showed that metal mixtures were inversely associated with E| and positively associated with FSH levels. No association was found between metals and testosterone levels. Results from this prospective cohort study demonstrate that environmental heavy metal exposures, including cadmium, mercury, and lead, may disturb circulating levels of E|, FSH, and SHBG in midlife women.
Subject:
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Bayes Theorem Cadmium Estradiol Female Follicle Stimulating Hormone Gonadal Steroid Hormones Humans Mercury Metals, Heavy Prospective Studies Testosterone Women's Health
Source:
Environ Pollut. 317:120740
Pubmed ID:
36436662
Pubmed Central ID:
PMC9897061
Document Type:
Journal Article
Funding:
T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; R01 AG062622/AG/NIA NIH HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; ... More +
T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; R01 AG062622/AG/NIA NIH HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; U01 AG012535/AG/NIA NIH HHSUnited States/ ; U01 AG012553/AG/NIA NIH HHSUnited States/ ; U01 NR004061/NR/NINR NIH HHSUnited States/ ; U01 AG012539/AG/NIA NIH HHSUnited States/ ; R01 ES026578/ES/NIEHS NIH HHSUnited States/ ; U01 AG012546/AG/NIA NIH HHSUnited States/ ; U19 AG063720/AG/NIA NIH HHSUnited States/ ; U01 AG012495/AG/NIA NIH HHSUnited States/ ; U01 AG012531/AG/NIA NIH HHSUnited States/ ; R01 ES026964/ES/NIEHS NIH HHSUnited States/ ; U01 AG017719/AG/NIA NIH HHSUnited States/ Less -
Name as Subject:
Study of Women’s Health Across the Nation
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d0d8e274b1c03b5bb1245dd8366b4861dd0103ea64e2c5833120170fc330159b
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