Maternal occupational exposure to chemicals and child cognitive function

Details

• Alternative Title:
  Pediatr Res
• Personal Author:
  Ish, Jennifer ; Symanski, Elaine ; Ruiz de Porras, David Gimeno ; Casas, Maribel ; Delclos, George L. ; Guxens, Mònica ; Ibarluzea, Jesús M. ; Iñiguez, Carmen ; Lertxundi, Aitana ; Rebagliato, Marisa ; Swartz, Michael D. ; Whitworth, Kristina W.
• Description:
  Background:
  
  Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine disrupting chemicals (EDCs).
  
  Methods:
  
  We included 1,058 mother-child pairs from the INfancia y Medio Ambiente (INMA) project (2003–2008). Using a job-exposure matrix, exposure probability scores for ten EDC groups were assigned to each mother based on her longest held job during pregnancy. At the child’s 5-year visit, the McCarthy Scales of Children’s Abilities was administered, yielding the general cognitive index and scales for specific cognitive domains. We analyzed region-specific associations between EDC exposures and each outcome separately using adjusted linear regression and combined region-specific effect estimates using random-effects meta-analyses.
  
  Results:
  
  Approximately 39% of women were exposed to at least one EDC group, but exposure to most individual EDC groups was low (<5%). Maternal organic solvent exposure was associated with lower quantitative scores among children (−5.8 points, 95% confidence interval: −11.0, −0.5). Though statistically non-significant, exposures to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds, and miscellaneous chemicals were associated with poorer offspring performance for most or all cognitive domains.
  
  Conclusions:
  
  This study found limited evidence for a role of maternal occupational EDC exposures on child cognition. Further research is needed to better characterize exposures among pregnant workers.
  
  
• Subjects:
  Cognition Endocrine Disruptors Female Humans Maternal Exposure Occupational Exposure Pesticides Polycyclic Aromatic Hydrocarbons Pregnancy Prospective Studies Solvents

  More +
• Source:
  Pediatr Res. 92(4):1153-1160
• Pubmed ID:
  35578010
• Pubmed Central ID:
  PMC9887679
• Document Type:
  Journal Article
• Funding:
  P30 ES030285/ES/NIEHS NIH HHSUnited States/ ; R01 ES028842/ES/NIEHS NIH HHSUnited States/ ; T42 OH008421/OH/NIOSH CDC HHSUnited States/ ; TPR 15-230/HX/HSRD VAUnited States/
• Volume:
  92
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:44a212ee1a5e118f77da106ff58bee654dc1e2dcb18a703ed2873a50ee15bb99cb32e2047cce658906d643143f59b9f0fd5870953cb1f7b5437bc92dd6555b57
• Download URL:
  https://stacks.cdc.gov/view/cdc/124157/cdc_124157_DS1.pdf
• File Type:
  [PDF - 858.65 KB ]