Observational Cohort Study of Evolving Epidemiologic, Clinical, and Virologic Features of Monkeypox in Southern France

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cassir, Nadim ; Cardona, Florian ; Tissot-Dupont, Hervé ; Bruel, Christiane ; Doudier, Barbara ; Lahouel, Salima ; Bendamardji, Karim ; Boschi, Céline ; Aherfi, Sarah ; Edouard, Sophie ; Lagier, Jean-Christophe ; Colson, Philippe ; Gautret, Philippe ; Fournier, Pierre-Edouard ; Parola, Philippe ; Brouqui, Philippe ; La-Scola, Bernard ; Million, Matthieu
• Description:
  We enrolled 136 patients with laboratory-confirmed monkeypox during June 4-August 31, 2022, at the University Hospital Institute Méditerranée Infection in Marseille, France. The median patient age was 36 years (interquartile range 31-42 years). Of 136 patients, 125 (92%) were men who have sex with men, 15 (11%) reported previous smallpox vaccinations, and 21 (15.5%) were HIV-positive. The most frequent lesion locations were the genitals (68 patients, 53%), perianal region (65 patients, 49%), and oral/perioral area (22 patients, 17%). Lesion locations largely corresponded with the route of contamination. Most (68%) patients had isolated anal, genital, or oral lesions when they were first seen, including 56 (61%) who had >1 positive site without a visible lesion. Concurrent sexually transmitted infections were diagnosed in 19 (15%) patients, and 7 patients (5%) were asymptomatic. We recommend vaccination campaigns, intensified testing for sexually transmitted infections, and increased contact tracing to control the ongoing monkeypox outbreak.
• Subjects:
  Adult Cohort Studies Emerging Communicable Diseases Female France Homosexuality, Male Humans Male Sexual And Gender Minorities Sexually Transmitted Diseases
• Source:
  Emerg Infect Dis. 2022; 28(12):2409-2415
• Pubmed ID:
  36241422
• Pubmed Central ID:
  PMC9707593
• Document Type:
  Journal Article
• Place as Subject:
  France
• Volume:
  28
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:911dcd76c497fc7c31b829018f69f8efea1d8be50b11dd101d4013fb6b2d812d
• Download URL:
  https://stacks.cdc.gov/view/cdc/123354/cdc_123354_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]