Paxlovid Associated with Decreased Hospitalization Rate Among Adults with COVID-19 - United States, April-September 2022

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Shah, Melisa M. ; Joyce, Brendan ; Plumb, Ian D. ; Sahakian, Sam ; Feldstein, Leora R. ; Barkley, Eric ; Paccione, Mason ; Deckert, Joseph ; Sandmann, Danessa ; Gerhart, Jacqueline L. ; Hagen, Melissa Briggs
• Description:
  Nirmatrelvir-ritonavir (Paxlovid), an oral antiviral treatment, is authorized for adults with mild-to-moderate COVID-19 who are at increased risk for progression to severe illness. However, real-world evidence on the benefit of Paxlovid, according to vaccination status, age group, and underlying health conditions, is limited. To examine the benefit of Paxlovid in adults aged ≥18 years in the United States, a large electronic health record (EHR) data set (Cosmos|) was analyzed to assess the association between receiving a prescription for Paxlovid and hospitalization with a COVID-19 diagnosis in the ensuing 30 days. A Cox proportional hazards model was used to estimate this association, adjusted for demographic characteristics, geographic location, vaccination, previous infection, and number of underlying health conditions. Among 699,848 adults aged ≥18 years eligible for Paxlovid during April-August 2022, 28.4% received a Paxlovid prescription within 5 days of COVID-19 diagnosis. Being prescribed Paxlovid was associated with a lower hospitalization rate among the overall study population (adjusted hazard ratio [aHR] = 0.49), among those who had received ≥3 mRNA COVID-19 vaccines (aHR = 0.50), and across age groups (18-49 years: aHR = 0.59; 50-64 years: aHR = 0.40; and ≥65 years: aHR = 0.53). Paxlovid should be prescribed to eligible adults to reduce the risk of COVID-19-associated hospitalization.
• Subjects:
  Adolescent Adult COVID-19 COVID-19 Testing COVID-19 Vaccines Hospitalization Humans Middle Aged Young Adult
• Source:
  MMWR Morbidity Mortal Weekly Rep. 71(48):1531-1537
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7148e2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  36454693
• Pubmed Central ID:
  PMC9721144
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  p.1531-1537 (7 pdf pages)
• Volume:
  71
• Issue:
  48
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:57f7f990b2ad3b3bf817640e393dc7fa966472a41e1c2b09c43d705738a6a71e2041c06c995eeaae3080b633ac5b8f729d8c6be20a985347c9b4bbcf64f46a90
• Download URL:
  https://stacks.cdc.gov/view/cdc/123163/cdc_123163_DS1.pdf
• File Type:
  [PDF - 165.48 KB ]