Factors Associated With Severe Illness in Patients Aged <21 Years Hospitalized for COVID-19

Choudhary, Rewa; Webber, Bryant J.; Womack, Lindsay S.; Dupont, Hannah K.; Chiu, Sophia K.; Wanga, Valentine; Gerdes, Megan E.; Hsu, Sophia; Shi, Dallas S.; Dulski, Theresa M.; Idubor, Osatohamwen I.; Wendel, Arthur M.; Agathis, Nickolas T.; Anderson, Kristi; Boyles, Tricia; Click, Eleanor S.; Da Silva, Juliana; Evans, Mary E.; Gold, Jeremy A.W.; Haston, Julia C.; Loga, Pamela; Maloney, Susan A.; Martinez, Marisol; Natarajan, Pavithra; Spicer, Kevin B.; Swancutt, Mark; Stevens, Valerie A.; Rogers-Brown, Jessica; Chandra, Gyan; Light, Megan; Barr, Frederick E.; Snowden, Jessica; Kociolek, Larry K.; McHugh, Matthew; Wessel, David L.; Simpson, Joelle N.; Gorman, Kathleen C.; Breslin, Kristen A.; DeBiasi, Roberta L.; Thompson, Aaron; Kline, Mark W.; Boom, Julie A.; Singh, Ila R.; Dowlin, Michael; Wietecha, Mark; Schweitzer, Beth; Morris, Sapna Bamrah; Koumans, Emilia H.; Ko, Jean Y.; Siegel, David A.; Kimball, Anne A.

doi:10.1542/hpeds.2022-006613

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Factors Associated With Severe Illness in Patients Aged <21 Years Hospitalized for COVID-19

9 01 2022
By Choudhary, Rewa ; Webber, Bryant J. ; Womack, Lindsay S. ; ...
http://dx.doi.org/10.1542/hpeds.2022-006613
Source: Hosp Pediatr. 12(9):760-783

[PDF-667.12 KB]

English

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Details:

Alternative Title:

Hosp Pediatr
Personal Author:

Choudhary, Rewa ; Webber, Bryant J. ; Womack, Lindsay S. ; Dupont, Hannah K. ; Chiu, Sophia K. ; ... More +

Choudhary, Rewa ; Webber, Bryant J. ; Womack, Lindsay S. ; Dupont, Hannah K. ; Chiu, Sophia K. ; Wanga, Valentine ; Gerdes, Megan E. ; Hsu, Sophia ; Shi, Dallas S. ; Dulski, Theresa M. ; Idubor, Osatohamwen I. ; Wendel, Arthur M. ; Agathis, Nickolas T. ; Anderson, Kristi ; Boyles, Tricia ; Click, Eleanor S. ; Da Silva, Juliana ; Evans, Mary E. ; Gold, Jeremy A.W. ; Haston, Julia C. ; Loga, Pamela ; Maloney, Susan A. ; Martinez, Marisol ; Natarajan, Pavithra ; Spicer, Kevin B. ; Swancutt, Mark ; Stevens, Valerie A. ; Rogers-Brown, Jessica ; Chandra, Gyan ; Light, Megan ; Barr, Frederick E. ; Snowden, Jessica ; Kociolek, Larry K. ; McHugh, Matthew ; Wessel, David L. ; Simpson, Joelle N. ; Gorman, Kathleen C. ; Breslin, Kristen A. ; DeBiasi, Roberta L. ; Thompson, Aaron ; Kline, Mark W. ; Boom, Julie A. ; Singh, Ila R. ; Dowlin, Michael ; Wietecha, Mark ; Schweitzer, Beth ; Morris, Sapna Bamrah ; Koumans, Emilia H. ; Ko, Jean Y. ; Siegel, David A. ; Kimball, Anne A. Less -
Description:

OBJECTIVES:

To describe coronavirus disease 2019 (COVID-19)–related pediatric hospitalizations during a period of B.1.617.2 (Δ) variant predominance and to determine age-specific factors associated with severe illness.

METHODS:

We abstracted data from medical charts to conduct a cross-sectional study of patients aged <21 years hospitalized at 6 United States children’s hospitals from July to August 2021 for COVID-19 or with an incidental positive severe acute respiratory syndrome coronavirus 2 test. Among patients with COVID-19, we assessed factors associated with severe illness by calculating age-stratified prevalence ratios (PR). We defined severe illness as receiving high-flow nasal cannula, positive airway pressure, or invasive mechanical ventilation.

RESULTS:

Of 947 hospitalized patients, 759 (80.1%) had COVID-19, of whom 287 (37.8%) had severe illness. Factors associated with severe illness included coinfection with respiratory syncytial virus (RSV) (PR 3.64) and bacteria (PR 1.88) in infants; RSV coinfection in patients aged 1 to 4 years (PR 1.96); and obesity in patients aged 5 to 11 (PR 2.20) and 12 to 17 years (PR 2.48). Having ≥2 underlying medical conditions was associated with severe illness in patients aged <1 (PR 1.82), 5 to 11 (PR 3.72), and 12 to 17 years (PR 3.19).

CONCLUSIONS:

Among patients hospitalized for COVID-19, factors associated with severe illness included RSV coinfection in those aged <5 years, obesity in those aged 5 to 17 years, and other underlying conditions for all age groups <18 years. These findings can inform pediatric practice, risk communication, and prevention strategies, including vaccination against COVID-19.
Subjects:

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Article Child Coinfection COVID-19 Cross-Sectional Studies Hospitalization Humans Infant Obesity Respiratory Syncytial Virus Infections SARS-CoV-2 United States
Source:

Hosp Pediatr. 12(9):760-783
Pubmed ID:

35670605
Pubmed Central ID:

PMC9773098
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

12
Issue:

9
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:338f1f47bbc9bc6a2a5fbff3dd2eea558dfdef055a49772a58f40e080a0f3979
Download URL:

https://stacks.cdc.gov/view/cdc/123024/cdc_123024_DS1.pdf
File Type:

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	nihms-1857223-f0001.jpg	jpeg
	nihms-1857223.nxml	xml
	NIHMS1857223-supplement-Supplementary_Material.pdf	pdf

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