Important Updates on COVID-19 Therapeutics for Treatment and Prevention [December 20, 2022, 5:45 PM ET]

Details

• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.). Health Alert Network (HAN)
• Description:
  December 20, 2022, 5:45 PM ET
  
  CDCHAN-00483
  
  The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Update to supplement the CDC HAN Health Advisories issued on April 25, 2022 and May 24, 2022 to emphasize to healthcare providers, public health departments, and the public that the majority of Omicron sublineages circulating in the United States have reduced susceptibility to the monoclonal antibody, bebtelovimab and the monoclonal antibody combination, cilgavimab and tixagevimab (EvusheldTM).
  
  Because of this reduced susceptibility, on November 30, 2022, the Food and Drug Administration (FDA) announced that the use of bebtelovimab is not currently authorized for use for patients with COVID-19. The monoclonal antibody combination, cilgavimab and tixagevimab (EvusheldTM), currently recommended for pre-exposure prophylaxis, remains authorized for persons with moderate to severe immunosuppression and for those whom vaccination with any available COVID-19 vaccine, according to the approved or authorized schedule, is not recommended due to a history of severe adverse reaction to a COVID-19 vaccine(s) and/or COVID-19 vaccine component(s). However, providers should be aware and communicate to patients that its effectiveness may be increasingly limited against circulating Omicron sublineages.
  
  Antiviral therapeutics for the treatment of COVID-19, ritonavir-boosted nirmatrelvir (PaxlovidTM), remdesivir (Veklury®), and molnupiravir (LagevrioTM), retain activity against currently circulating Omicron sublineages. These medications can prevent severe disease, hospitalization, and death and are widely available but have been underused.
  
  This HAN Health Update provides health care professionals, public health officials, and the public with guidance on improving use of therapeutics for treatment of COVID-19 and strategies to prevent serious outcomes of COVID-19.
  
  
• Content Notes:
  Notice of Possible Alert Expiration: The CDC Health Alert, Advisory, Update, and Info Service announcements, distributed by the Health Alert Network (HAN), were active on the date they were originally published. Publication dates have been added to Titles for clarity. A CDC Health Alert, Advisory, Update, and Info Service announcement may expire at any time. They may also be updated or superseded according to later developments. None of the CDC Health Alert, Advisory, Update, or Info Service announcements in the Stacks HAN Collection should be assumed to be current or active. Stacks preserves HAN announcements in order to maintain a record of past CDC actions. Stacks in not designed for up-to-the-minute notifications. For the list of current CDC Health Alert, Advisory, Update, or Info Service announcements, patrons should visit the Health Alert Network (HAN) webpage at https://www.cdc.gov/han/php/about/index.html. For up to the minute reports, subscribe to the HAN email alert system hosted by CDC News & Updates at https://tools.cdc.gov/campaignproxyservice/subscriptions.aspx?topic_id=USCDC_486
  
  Categories of Health Alert Network (HAN) messages:
  
  Health Alert: Requires immediate action or attention, highest level of importance.
  
  Health Advisory: May not require immediate action; provides important information for a specific incident or situation.
  
  Health Update: Unlikely to require immediate action; provides updated information regarding an incident or situation.
  
  HAN Info Service: Does not require immediate action; provides general public health information.
  
  
• Subjects:
  COVID-19/prevention & Control COVID-19/therapy
• Keywords:
  HAN Health Alert Network
• Source:
  HAN ; 482
• Series:
  Health Alert Network
• Subseries:
  CDC Health Update
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Document Type:
  Text
• Genre:
  Alert
• Place as Subject:
  United States
• Rights:
  Public Domain
• Issue:
  00482
• Collection(s):
  Health Alert Network (HAN)
• Main Document Checksum:
  urn:sha-512:dbb2f49aa22ec847312cb6c0adb6c206028f95bbe8514132b59c34633dff5af0bc20a752fb3356df3c2ee2dcc017681f4e69cfb28860a0f1f7ce4dea2db25bad
• Download URL:
  https://stacks.cdc.gov/view/cdc/122922/cdc_122922_DS1.pdf
• File Type:
  [PDF - 222.13 KB ]