Estimated time from HIV infection to diagnosis and diagnosis to first viral suppression during 2014–2018

Details

• Alternative Title:
  AIDS
• Personal Author:
  CREPAZ, Nicole ; SONG, Ruiguang ; LYSS, Sheryl B. ; HALL, H. Irene
• Description:
  Objective:
  
  To examine changes in the lengths of time from HIV infection to diagnosis (Infx-to-Dx) and from diagnosis to first viral suppression (Dx-to-VS), two periods during which HIV can be transmitted.
  
  Design:
  
  Data from the National HIV Surveillance System (NHSS) for persons who were aged ≥13 years at the time of HIV diagnosis during 2014–2018 and resided in one of 33 U.S. jurisdictions with complete laboratory reporting.
  
  Methods:
  
  The date of HIV infection was estimated based on a CD4-depletion model. Date of HIV diagnosis, and dates and results of first CD4 test and first viral suppression (<200 copies/mL) after diagnosis were reported to NHSS through December 2019. Trends for Infx-to-Dx and Dx-to-VS intervals were examined using estimated annual percentage change.
  
  Results:
  
  During 2014–2018, among persons aged ≥13 years, 133,413 HIV diagnoses occurred. The median length of infx-to-Dx interval shortened from 43 months (2014) to 40 months (2018), a 1.5% annual decrease (7.0% relative change over the 5-year period). The median length of Dx-to-VS interval shortened from 7 months (2014) to 4 months (2018), an 11.4% annual decrease (42.9% relative change over the 5-year period). Infx-to-Dx intervals shortened in only some subgroups, while Dx-to-VS intervals shortened in all groups by sex, transmission category, race/ethnicity, age, and CD4 count at diagnosis.
  
  Conclusion:
  
  The shortened Infx-to-Dx and Dx-to-VS intervals suggest progress in promoting HIV testing and earlier treatment; however, diagnosis delays continue to be substantial. Further shortening both intervals and eliminating disparities are needed to achieve Ending the HIV Epidemic goals.
  
  
• Subjects:
  Article CD4 Lymphocyte Count Ethnicity HIV Diagnosis Delay HIV Infection HIV Infections HIV Testing Humans Time To Viral Suppression United States Viral Load

  More +
• Source:
  AIDS. 35(13):2181-2190
• Pubmed ID:
  34172670
• Pubmed Central ID:
  PMC9647140
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  35
• Issue:
  13
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:30b73e6a72bf003b17b9a4e159106c9702fd573d64cfa0c31d022d6383174757
• Download URL:
  https://stacks.cdc.gov/view/cdc/122194/cdc_122194_DS1.pdf
• File Type:
  [PDF - 189.52 KB ]