COVID-19 Severity and Mortality Among Chronic Liver Disease Patients: A Systematic Review and Meta-Analysis

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  Nagarajan, Ramya ; Krishnamoorthy, Yuvaraj ; Rajaa, Sathish ; Hariharan, Vishnu Shankar
• Description:
  Introduction
  
  Pre-existing comorbid conditions in COVID-19 patients are risk factors for developing severe disease and death. We aimed to determine the association of chronic liver disease (CLD), a comorbid condition, with severity of disease and death among COVID-19 patients.
  
  Methods
  
  We searched for studies reporting COVID-19 outcomes among CLD and non-CLD patients in databases including Medline, EMBASE, ScienceDirect, Google Scholar, and Cochrane Library from inception of the pandemic until February 2022. Risk of bias assessment was conducted by using the Newcastle-Ottawa Scale for assessing the quality of nonrandomized studies in meta-analyses. We conducted a meta-analysis with a random-effects model and reported pooled odds ratios (ORs) with 95% CIs.
  
  Results
  
  We included 40 studies with 908,032 participants. Most studies were conducted in China and the US. COVID-19 patients with CLD had significantly higher odds of having a severe form of COVID-19 (pooled OR = 2.44; 95% CI, 1.89–3.16) and death (pooled OR = 2.35; 95% CI, 1.85–3.00) when compared with COVID-19 patients without CLD.
  
  Conclusion
  
  The presence of CLD is significantly related to adverse clinical outcomes among COVID-19 patients in terms of severity and mortality. Clinicians should develop a comprehensive intervention plan to manage these high-risk patients and reduce COVID-19–related deaths.
  
  
• Subjects:
  Comorbidity COVID-19 Humans Liver Diseases Pandemics Risk Factors
• Source:
  Prev Chronic Dis. 2022; 19
• DOI:
  http://dx.doi.org/10.5888/pcd19.210228
• ISSN:
  1545-1151
• Pubmed ID:
  36007255
• Pubmed Central ID:
  PMC9480842
• Document Type:
  Journal Article
• Genre:
  Systematic Review
• Volume:
  19
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:22bafdab6a74a815d696f39c92da472e46e71f70fb3fb45f3e8dc0bbd98fd32e180cfce70532614737c13878f9e9eca33fb1d32db2a597060319a11e1d2ba4b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/122181/cdc_122181_DS1.pdf
• File Type:
  [PDF - 779.39 KB ]