Details:

Alternative Title:
Vaccines (Basel)
Personal Author:
Sayedahmed, Ekramy E. ; Elkashif, Ahmed ; Alhashimi, Marwa ; Sambhara, Suryaprakash ; Mittal, Suresh K.
Sayedahmed, Ekramy E. ; Elkashif, Ahmed ; Alhashimi, Marwa ; Sambhara, Suryaprakash ; Mittal, Suresh K. Less -
Description:
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health. However, this does not account for the threat influenza poses on public health. The currently licensed seasonal influenza vaccines primarily confer excellent strain-specific protection. In addition to the seasonal influenza viruses, the emergence and spread of avian influenza pandemic viruses such as H5N1, H7N9, H7N7, and H9N2 to humans have highlighted the urgent need to adopt a new global preparedness for an influenza pandemic. It is vital to explore new strategies for the development of effective vaccines for pandemic and seasonal influenza viruses. The new vaccine approaches should provide durable and broad protection with the capability of large-scale vaccine production within a short time. The adenoviral (Ad) vector-based vaccine platform offers a robust egg-independent production system for manufacturing large numbers of influenza vaccines inexpensively in a short timeframe. In this review, we discuss the progress in the development of Ad vector-based influenza vaccines and their potential in designing a universal influenza vaccine.
Subjects:
[+]
Adenoviral Vector Human Adenoviral Vector Influenza Vaccine Nonhuman Adenoviral Vector Review Universal Influenza Vaccine
Source:
Vaccines (Basel). 2020; 8(4)
Pubmed ID:
33019589
Pubmed Central ID:
PMC7712206
Document Type:
Journal Article
Funding:
R01 AI059374/AI/NIAID NIH HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9f6d65c2afbfba0f2363ad3b9a75f900b8704e841d3287e78b9ea853430af2c1
Download URL:
https://stacks.cdc.gov/view/cdc/122152/cdc_122152_DS1.pdf
File Type:

Supporting Files

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