Influenza Virus Infects and Depletes Activated Adaptive Immune Responders

Details

• Alternative Title:
  Adv Sci (Weinh)
• Personal Author:
  Bohannon, Caitlin D. ; Ende, Zachary ; Cao, Weiping ; Mboko, Wadzanai P. ; Ranjan, Priya ; Kumar, Amrita ; Mishina, Margarita ; Amoah, Samuel ; Gangappa, Shivaprakash ; Mittal, Suresh K. ; Lovell, Jonathan F. ; García‐Sastre, Adolfo ; Pfeifer, Blaine A. ; Davidson, Bruce A. ; Knight, Paul ; Sambhara, Suryaprakash
• Description:
  Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and significantly factored into the severity of the 1918, 1968, and 2009 pandemics. Furthermore, there is an increased incidence of other respiratory infections even in vaccinated individuals during influenza season. Putative mechanisms responsible for vaccine failures against influenza as well as other respiratory infections during influenza season are investigated. Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen-specific responses to influenza, measles, and varicella. The observations made in humans to a mouse model to unravel the mechanism is confirmed and extended. Infection with influenza virus suppresses an ongoing adaptive response to vaccination against influenza as well as other respiratory pathogens, i.e., Adenovirus and Streptococcus pneumoniae by preferentially infecting and killing activated lymphocytes which express elevated levels of sialic acid receptors. These findings propose a new mechanism for the high incidence of secondary respiratory infections due to bacteria and other viruses as well as vaccine failures to influenza and other respiratory pathogens even in immune individuals due to influenza viral infections.
• Subjects:
  Adaptive Immunity Adenovirus Animals Disease Models, Animal Female Flowcytometry Humans Immunosuppression Influenza Influenza, Human Mice Mice, Inbred BALB C Pneumococcus Research Article Research Articles

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• Source:
  Adv Sci (Weinh). 8(16)
• Pubmed ID:
  34189857
• Pubmed Central ID:
  PMC8373117
• Document Type:
  Journal Article
• Funding:
  R01 HL151498/HL/NHLBI NIH HHSUnited States/ ; R01 AI059374/AI/NIAID NIH HHSUnited States/ ; HHSN272201400008C/AI/NIAID NIH HHSUnited States/ ; HL151498/HL/NHLBI NIH HHSUnited States/ ; 75N93019R00028/Center for Research on Influenza Pathogenesis and Transmission/ ; R21 AG064215/AG/NIA NIH HHSUnited States/ ; Centers of Excellence for Influenza Research and Response/ ; AG064215/National Institute of Allergy and Infectious Diseases/ ; CC/CDC HHSUnited States/
• Volume:
  8
• Issue:
  16
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ee90ea973ecb7854fbb09e2ba494d325e0a4fbbde720e7ce8faeb65cf083cbc5
• Download URL:
  https://stacks.cdc.gov/view/cdc/122142/cdc_122142_DS1.pdf
• File Type:
  [PDF - 5.21 MB ]