Prevalence of Histoplasmosis among Persons with Advanced HIV Disease, Nigeria

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Oladele, Rita O. ; Osaigbovo, Iriagbonse I. ; Akanmu, Alani S. ; Adekanmbi, Olukemi A. ; Ekeng, Bassey E. ; Mohammed, Yahaya ; Alex-Wele, Mary A. ; Okolo, Mark O. ; Ayanbeku, Stephen T. ; Unigwe, Uchechukwu S. ; Akase, Iorhen E. ; Dan-Jumbo, Alali ; Isralski, Dennis ; Denning, David W. ; Pasqualotto, Alessandro C. ; Chiller, Tom
• Description:
  We sought to determine the prevalence of probable disseminated histoplasmosis among advanced HIV disease (AHD) patients in Nigeria. We conducted a cross-sectional study in 10 sites across 5 of 6 geopolitical zones in Nigeria. We identified patients with urinary samples containing CD4 cell counts <200 cells/mm| or World Health Organization stage 3 or 4 disease who also had >2 clinical features of disseminated histoplasmosis, and we tested them for Histoplasma antigen using a Histoplasma enzyme immune assay. Of 988 participants we recruited, 76 (7.7%) were antigen-positive. The 76 Histoplasma antigen-positive participants had significantly lower (p = 0.03) CD4 counts; 9 (11.8%) were also co-infected with tuberculosis. Most antigen-positive participants (50/76; 65.8%; p = 0.015) had previously received antiretroviral treatment; 26/76 (34.2%) had not. Because histoplasmosis is often a hidden disease among AHD patients in Nigeria, Histoplasma antigen testing should be required in the AHD package of care.
• Subjects:
  Cross-Sectional Studies Fungi Histoplasma Histoplasmosis Hiv/Aids And Other Retroviruses Hiv Infections Humans Infections Nigeria Prevalence Prevalence Of Histoplasmosis Among Persons With Advanced Hiv Disease, Nigeria Research Respiratory Infections Tuberculosis And Other Mycobacteria

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• Source:
  Emerg Infect Dis. 2022; 28(11):2261-2269
• Pubmed ID:
  36286009
• Pubmed Central ID:
  PMC9622240
• Document Type:
  Journal Article
• Place as Subject:
  Nigeria
• Volume:
  28
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:549605d48d936baa9e5f68013e5d4e8dffa3af9f5f9e8cac40e729e65d06db14
• Download URL:
  https://stacks.cdc.gov/view/cdc/122131/cdc_122131_DS1.pdf
• File Type:
  [PDF - 955.66 KB ]