Determinants of Serum Concentrations of Lipopolysaccharide-Binding Protein (LBP) in the Adult Population: The Role of Obesity

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Gonzalez-Quintela, Arturo ; Alonso, Manuela ; Campos, Joaquin ; Vizcaino, Luis ; Loidi, Lourdes ; Gude, Francisco
• Description:
  Background and Aim
  
  Assessment of serum concentration of lipopolysaccharide (LPS)-binding protein (LBP) has been suggested as a useful biomarker to indicate activation of innate immune responses to microbial products. We investigated LBP concentrations and associations with demographics, lifestyle factors, and common metabolic abnormalities in adults. We also examined if LBP concentrations were associated with common polymorphisms in genes coding for LBP (rs2232618), CD14 (rs2569190), and TLR4 (rs4986790), the molecules responsible for the innate immune response to LPS, or serum levels of soluble CD14 (sCD14) and proinflammatory cytokines.
  
  Methods
  
  Serum LBP was measured with a commercial immunoassay in a random sample of the adult population (n = 420, 45% males, age 18–92 years) from a single municipality.
  
  Results
  
  Serum LBP concentrations increased with age (P<0.001) and were higher in individuals who were overweight or obese than in normal-weight individuals (P<0.001). Similarly, LBP concentrations were higher in individuals with metabolic syndrome than in individuals without it (P<0.001). Among metabolic syndrome components, LBP concentrations were independently associated with abdominal obesity (P = 0.002) and low concentrations of HDL-cholesterol (P<0.001). Serum LBP concentrations tended to be independently associated with smoking (P = 0.05), but not with alcohol consumption. Likewise, there was not significant association between LBP concentrations and gene polymorphisms. Concentrations of LBP significantly correlated with serum levels of proinflammatory cytokines (IL-6 and IL-8), sCD14, and with liver enzymes.
  
  Conclusions
  
  Serum LBP concentrations increased with age. Overweight, obesity, and having metabolic syndrome (particularly, low HDL cholesterol levels) were associated with higher LBP concentrations. These findings are consistent with microbial exposure playing a role in these inflammatory, metabolic abnormalities.
  
  
• Subjects:
  Acute-Phase Proteins Adolescent Adult Age Factors Antigens, CD14 Carrier Proteins Female Genetic Association Studies Humans Immunity, Innate Inflammation Male Membrane Glycoproteins Metabolic Syndrome X Middle Aged Obesity Polymorphism, Single Nucleotide Toll-Like Receptor 4

  More +
• Source:
  PLoS One. 2013; 8(1).
• Document Type:
  Journal Article
• Volume:
  8
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:80e7bc0f6d3d042654a2d1c77415fa52a1b5b4336ec90933d26e7bedf245306a
• Download URL:
  https://stacks.cdc.gov/view/cdc/12193/cdc_12193_DS1.pdf
• File Type:
  [PDF - 288.49 KB ]