Polio by the Numbers – A Global Perspective

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Badizadegan, Kamran ; Kalkowska, Dominika A. ; Thompson, Kimberly M.
• Description:
  Background:
  
  Investments in national immunization programs and the Global Polio Eradication Initiative (GPEI) have resulted in substantial reductions in paralytic polio worldwide. However, cases prevented because of investments in immunization programs and GPEI remain incompletely characterized.
  
  Methods:
  
  Using a global model that integrates polio transmission, immunity, and vaccine dynamics, we provide estimates of polio incidence and numbers of paralytic cases prevented. We compare the results with reported cases and estimates historically published by the World Health Organization.
  
  Results:
  
  We estimate that the existence and use of polio vaccines prevented 5 million cases of paralytic polio between 1960–1987 and 24 million cases worldwide for 1988–2021 compared to a counterfactual world with no polio vaccines. Since the 1988 resolution to eradicate polio, our estimates suggest GPEI prevented 2.5 to 6 million cases of paralytic polio compared to counterfactual worlds without GPEI that assume different levels of intensity of polio vaccine use in routine immunization programs.
  
  Discussion:
  
  Analysis of historical cases provides important context for understanding and communicating the benefits of investments made in polio eradication. Prospective studies will need to explore the expected benefits of future investments, the outcomes of which will depend on whether and when polio is globally eradicated.
  
  
• Subjects:
  Article Disease Eradication Global Health Humans Immunization Programs Modeling Polio Poliomyelitis Poliovirus Vaccines Prevention Prospective Studies Vaccines

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• Source:
  J Infect Dis. 226(8):1309-1318
• Pubmed ID:
  35415741
• Pubmed Central ID:
  PMC9556648
• Document Type:
  Journal Article
• Funding:
  NU2RGH001915/ImCDC/Intramural CDC HHSUnited States/ ; 5NU2RGH001915-01-00/CC/CDC HHSUnited States/
• Volume:
  226
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:49cd86df1a254c4008d82b28301f465a99027d7867dcdc64fa1a24bc222da0ed
• Download URL:
  https://stacks.cdc.gov/view/cdc/121807/cdc_121807_DS1.pdf
• File Type:
  [PDF - 1.34 MB ]