Effect of Screening and Treatment for Gonorrhea and Chlamydia on HIV Incidence among Men who Have Sex with Men in the United States: A Modeling Analysis

Details

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Jones, Jeb ; Le Guillou, Adrien ; Gift, Thomas L. ; Chesson, Harrell ; Bernstein, Kyle ; Delaney, Kevin ; Lyles, Cynthia ; Berruti, Andres ; Sullivan, Patrick S. ; Jenness, Samuel M.
• Description:
  Background:
  
  Previous models have estimated the total population attributable fraction of NG/CT on HIV incidence among men who have sex with men (MSM), but this does not represent realistic intervention effects. We estimated the potential impact of screening for NG/CT on downstream incidence of HIV among MSM.
  
  Methods:
  
  Using a network model, we estimated the effects of varying coverage levels for STI screening among different priority populations: all sexually active MSM regardless of HIV serostatus, MSM with multiple recent (past 6 months) sex partners regardless of serostatus, MSM without HIV, and MSM with HIV. Under the assumption that all screening events included a urethral test, we also examined the effect of increasing of the proportion of screening events that include rectal screening for NG/CT on HIV incidence.
  
  Results:
  
  Increasing annual NG/CT screening among sexually active MSM by 60% averted 4.7% of HIV infections over a 10-year period (interquartile range (IQR): 2.3, 7.3). More HIV infections were averted when screening was focused on MSM with multiple recent sex partners: 60% coverage among MSM with multiple recent sex partners averted 9.8% of HIV infections (IQR: 8.1, 11.6). Increased STI screening among MSM without HIV averted more new HIV infections compared to the transmissions averted due to screening MSM with HIV, but fewer NG/CT tests were needed among MSM with HIV to avert a single new HIV infection.
  
  Conclusions:
  
  NG/CT screening among MSM is expected to lead to modest but clinically relevant reductions in HIV incidence among MSM.
  
  
• Subjects:
  Chlamydia Infections Chlamydia Trachomatis Gonorrhea HIV Infections Homosexuality, Male Humans Incidence Male Mass Screening Neisseria Gonorrhoeae Sexual And Gender Minorities United States

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• Keywords:
  Chlamydia Gonorrhea HIV Incidence Screening
• Source:
  Sex Transm Dis.
• Pubmed ID:
  35921635
• Pubmed Central ID:
  PMC9481699
• Document Type:
  Journal Article
• Funding:
  NU38PS004650/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI138783/AI/NIAID NIH HHSUnited States/ ; R21 MH112449/MH/NIMH NIH HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:cedbfbea9af95b590b57a3ff5562eb9f25fbcafbddc9835613468e438b0ea39a37e4eed6ca61248ebf692595c74c34f5e079a38db9fb01f62efa23ac61ee9c50
• Download URL:
  https://stacks.cdc.gov/view/cdc/121275/cdc_121275_DS1.pdf
• File Type:
  [PDF - 126.40 KB ]