Hispanic Ethnicity Differences in Birth Characteristics, Maternal Birth Place, and Risk of Early-Onset Hodgkin Lymphoma: A Population-Based Case-Control Study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Graham, Connor ; Metayer, Catherine ; Morimoto, Libby M. ; Wiemels, Joseph L. ; Siddique, Arfan ; Di, Mengyang ; Rodwin, Rozalyn L. ; Kadan-Lottick, Nina S. ; Ma, Xiaomei ; Wang, Rong
• Description:
  Background:
  
  Hispanic ethnicity differences in the risk of early-onset Hodgkin lymphoma (HL) diagnosed at < 40 years are understudied. We conducted a population-based case-control study to evaluate associations between birth characteristics and early-onset HL with a focus on potential ethnic differences.
  
  Methods:
  
  This study included 1,651 non-Hispanic White and 1,168 Hispanic cases with HL endorsing a range of races diagnosed at the age of 0-37 years during 1988-2015 and 140,950 controls without cancer matched on race/ethnicity and year of birth from the California Linkage Study of Early-Onset Cancers. Odds ratios (OR) and 95% confidence intervals (CI) were estimated from multivariable logistic regression models.
  
  Results:
  
  Having a foreign-born mother versus a United States-born mother (i.e., the reference group) was associated with an increased risk of early onset HL among non-Hispanic Whites (OR=1.52, 95% CI:1.31-1.76; P<0.01) and a decreased risk among Hispanics (OR=0.78, 95% CI:0.69-0.88; P<0.01). Among both race groups, risk of early onset HL increased with birthweight and maternal age (all P-trends<0.01). Among Non-Hispanic Whites, each 5-year increase in maternal age (OR = 1.11; 95% CI, 1.04-1.18; P-trend < 0.01) and paternal age (OR=1.07, 95% CI:1.02-1.13; P-trend=0.01) was associated with increased risk of early onset HL. Compared to female Hispanics, male Hispanics had an increased risk of early onset HL (OR =1.26, 95% CI:1.12-1.42; P<0.01).
  
  Conclusion:
  
  Maternal birthplace may play a role in risk of early-onset HL that differs by ethnicity.
  
  Impact:
  
  The ethnic differences observed between certain birth characteristics, maternal birthplace and early onset HL raise questions about the underlying biological, generational, lifestyle, residential, and genetic contributions to the disease.
  
  
• Subjects:
  Adolescent Adult Case-Control Studies Child Child, Preschool Ethnicity Female Hispanic Or Latino Hodgkin Disease Humans Infant Infant, Newborn Male Racial Groups Young Adult

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 31(9):1788-1795
• Pubmed ID:
  35709749
• Pubmed Central ID:
  PMC9444874
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  31
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fec27c2a19240f38222e2e91844054031c23654eb22c4c84b9f4891f77c6c050
• Download URL:
  https://stacks.cdc.gov/view/cdc/121074/cdc_121074_DS1.pdf
• File Type:
  [PDF - 412.87 KB ]