Orthopoxvirus Testing Challenges for Persons in Populations at Low Risk or Without Known Epidemiologic Link to Monkeypox — United States, 2022

Details

• Personal Author:
  Minhaj, Faisal S. ; Petras, Julia K. ; Brown, Jennifer A. ; Mangla, Anil T. ; Russo, Kelly ; Willut, Christina ; Lee, Michelle ; Beverley, Jason ; Harold, Rachel ; Milroy, Lauren ; Pope, Brian ; Gould, Emily ; Beeler, Cole ; Schneider, Jack ; Mostafa, Heba H. ; Godfred-Cato, Shana ; Click, Eleanor S. ; Borah, Brian F. ; Galang, Romeo R. ; Cash-Goldwasser, Shama ; Wong, Joshua M. ; McCormick, David W. ; Yu, Patricia A. ; Shelus, Victoria ; Carpenter, Ann ; Schatzman, Sabrina ; Lowe, David ; Townsend, Michael B. ; Davidson, Whitni ; Wynn, Nhien T. ; Satheshkumar, Panayampalli S. ; O’Connor, Siobhán M. ; O’Laughlin, Kevin ; Rao, Agam K. ; McCollum, Andrea M. ; Negrón, María E. ; Hutson, Christina L. ; Salzer, Johanna S.
• Corporate Authors:
  CDC Monkeypox Emergency Response Team. ; Centers for Disease Control and Prevention (U.S.). Epidemic Intelligence Service. ; Indiana. Department of Health. ; District of Columbia. Department of Health. ; Howard County (Md.). Health Department. ; Indiana University School of Medicine. ; Johns Hopkins Medical Institute. ; Centers for Disease Control and Prevention (U.S.). Laboratory Leadership Service.
• Description:
  What is already known about this topic? Testing for Monkeypox virus, using Food and Drug Administration 510(k)–cleared non-variola Orthopoxvirus real-time polymerase chain reaction (PCR) test and laboratory developed real-time PCR tests, is critical for diagnosis of suspected cases.
  
  What is added by this report? Three persons with atypical rashes, uncharacteristic illnesses, and absence of risk factors or an epidemiologic link to a known monkeypox case received false-positive real-time PCR test results; late cycle threshold values were all ≥34.
  
  What are the implications for public health practice? When testing specimens from patients with atypical signs and symptoms or without epidemiologic links or risk factors or where these are unknown, laboratories should reextract and retest specimens with real-time PCR Ct values that are high (≥34) to avoid unnecessary medical treatment and expenditure of public health resources.
  
  Suggested citation for this article: Minhaj FS, Petras JK, Brown JA, et al. Orthopoxvirus Testing Challenges for Persons in Populations at Low Risk or Without Known Epidemiologic Link to Monkeypox — United States, 2022. MMWR Morb Mortal Wkly Rep. ePub: 2 September 2022.
  
  mm7136e1.htm?s_cid=mm7136e1_x
  
  
• Subjects:
  Disease Outbreaks Mpox (monkeypox)/diagnosis Reagent Kits, Diagnostic
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:36a61666995c284ca05a8c9b054f0954c797e8a239a8cc601f99e374e01f46ed65619197bbd76dbae5a917b29fdacf2c79579e1b594128e95b972735766339fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/120875/cdc_120875_DS1.pdf
• File Type:
  [PDF - 1.25 MB ]