Effectiveness of Pfizer-BioNTech mRNA Vaccination Against COVID-19 Hospitalization Among Persons Aged 12–18 Years — United States, June–September 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Olson, Samantha M. ; Newhams, Margaret M. ; Halasa, Natasha B. ; Price, Ashley M. ; Boom, Julie A. ; Sahni, Leila C. ; Irby, Katherine ; Walker, Tracie C. ; Schwartz, Stephanie P. ; Pannaraj, Pia S. ; Maddux, Aline B. ; Bradford, Tamara T. ; Nofziger, Ryan A. ; Boutselis, Benjamin J. ; Cullimore, Melissa L. ; Mack, Elizabeth H. ; Schuster, Jennifer E. ; Gertz, Shira J. ; Cvijanovich, Natalie Z. ; Kong, Michele ; Cameron, Melissa A. ; Staat, Mary A. ; Levy, Emily R. ; Chatani, Brandon M. ; Chiotos, Kathleen ; Zambrano, Laura D. ; Campbell, Angela P. ; Patel, Manish M. ; Randolph, Adrienne G. ; Murdock, Meghan ; Glas Gaspers, Mary ; Typpo, Katri V. ; Kelley, Connor P. ; Sanders, Ronald C. ; Yates, Masson ; Smith, Chelsea ; Crane, Katheryn ; Lionetti, Geraldina ; Murcia-Montoya, Juliana ; Zinter, Matt S. ; Villarreal-Chico, Denise ; Skura, Adam L. ; Hakimi, Daniel ; Peralta, Harvey ; Port, Emily ; Carson, Imogene A. ; Lockwood, Justin M. ; Kamidani, Satoshi ; Tarquinio, Keiko M. ; Taylor, Caitlen E. ; Michelson, Kelly N. ; Coates, Bria M. ; Johnston, Marla S. ; Kucukak, Suden ; Chen, Sabrina R. ; Orzel, Amber O. ; Weller, Edie ; Berbert, Laura ; He, Jie ; Heidemann, Sabrina M. ; Hume, Janet R. ; Bruno, Ellen R. ; Goertzen, Lexie A. ; Behl, Supriya ; Drapeau, Noelle M. ; Hill, Shannon M. ; Kietzman, Abigail ; Rinehart, Valerie ; Hoody, Lauren A. ; Navas, Angelo G. ; Bennett, Paris C. ; Twinem, Nicole A. ; Tomcany, Merry L. ; Rohlfs, Chelsea C. ; Douglas, Rebecca L. ; Bickford, Megan M. ; Wakefield, Lauren E. ; Nicotera, Janet B. ; Golchha, Meenakshi ; Oates, Jennifer N.
• Corporate Authors:
  Overcoming COVID-19 Investigators
• Description:
  Pfizer-BioNTech COVID-19 vaccine is authorized for use in children and adolescents aged 12-15 years and is licensed by the Food and Drug Administration (FDA) for persons aged ≥16 (1). A randomized placebo-controlled trial demonstrated an efficacy of 100% (95% confidence interval [CI] = 75.3%-100%) in preventing outpatient COVID-19 in persons aged 12-15 years (2); however, data among adolescents on vaccine effectiveness (VE) against COVID-19 in real-world settings are limited, especially among hospitalized patients. In early September 2021, U.S. pediatric COVID-19 hospitalizations reached the highest level during the pandemic (3,4). In a test-negative, case-control study at 19 pediatric hospitals in 16 states during June 1-September 30, 2021, the effectiveness of 2 doses of Pfizer-BioNTech vaccine against COVID-19 hospitalization was assessed among children and adolescents aged 12-18 years. Among 464 hospitalized persons aged 12-18 years (179 case-patients and 285 controls), the median age was 15 years, 72% had at least one underlying condition, including obesity, and 68% attended in-person school. Effectiveness of 2 doses of Pfizer-BioNTech vaccine against COVID-19 hospitalization was 93% (95% CI = 83%-97%), during the period when B.1.617.2 (Delta) was the predominant variant. This evaluation demonstrated that 2 doses of Pfizer-BioNTech vaccine are highly effective at preventing COVID-19 hospitalization among persons aged 12-18 years and reinforces the importance of vaccination to protect U.S. youths against severe COVID-19.
• Subjects:
  Adolescent Child COVID-19 COVID-19 Vaccines Female Hospitalization Humans Male Vaccines, Synthetic
• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(42):1483-1488
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7042e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  34673751
• Pubmed Central ID:
  PMC9361838
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  42
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:86beb5eab22595b2818e48d3b9a60cb8da237ab29fcfaf36b9670f65ee4850651cfd5f958852897230f17b86073509fa60cb1a8e17c0b0e2e95922c288532f2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/120636/cdc_120636_DS1.pdf
• File Type:
  [PDF - 125.63 KB ]