Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years — United States, January–March 2021

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Tenforde, Mark W. ; Olson, Samantha M. ; Self, Wesley H. ; Talbot, H. Keipp ; Lindsell, Christopher J. ; Steingrub, Jay S. ; Shapiro, Nathan I. ; Ginde, Adit A. ; Douin, David J. ; Prekker, Matthew E. ; Brown, Samuel M. ; Peltan, Ithan D. ; Gong, Michelle N. ; Mohamed, Amira ; Khan, Akram ; Exline, Matthew C. ; Files, D. Clark ; Gibbs, Kevin W. ; Stubblefield, William B. ; Casey, Jonathan D. ; Rice, Todd W. ; Grijalva, Carlos G. ; Hager, David N. ; Shehu, Arber ; Qadir, Nida ; Chang, Steven Y. ; Wilson, Jennifer G. ; Gaglani, Manjusha ; Murthy, Kempapura ; Calhoun, Nicole ; Monto, Arnold S. ; Martin, Emily T. ; Malani, Anurag ; Zimmerman, Richard K. ; Silveira, Fernanda P. ; Middleton, Donald B. ; Zhu, Yuwei ; Wyatt, Dayna ; Stephenson, Meagan ; Baughman, Adrienne ; Womack, Kelsey N. ; Hart, Kimberly W. ; Kobayashi, Miwako ; Verani, Jennifer R. ; Patel, Manish M. ; Amosu, Omowunmi ; Armbruster, Brent ; Aston, Valerie ; Bernardo, Marianne ; Bowers, Robert ; De Souza, Leslie ; Friedel, Jennifer ; Gardner, Kevin ; Goff, Jennifer ; Gordon, Alexandra June ; Hendrickson, Audrey ; Hicks, Madeline ; Howell, Michelle ; Johnson, Jakea ; Jorgensen, Jeffrey ; Karow, Sarah ; Kozikowski, Lori ; Krol, Olivia ; Landreth, Leigha ; LaRose, Mary ; Lopez, Brenda ; York, New ; Luong, Andrea ; McClellan, Bob ; Maruggi, Ellen ; Miller, Karen ; Nair, Rahul ; Parks, Lisa ; Peers, Jennifer ; Perez, Cynthia ; Rivera, Adreanne ; Roque, Jonasel ; Santana, Andres ; Scharber, Tyler ; Silverman, Emma ; Tozier, Michael ; Tzehaie, Hiwet ; Zouyed, Zachary ; Arroliga, Alejandro ; Bagiatis, Alicia ; Balasubramani, GK ; Cheng, Caroline K. ; Eng, Heather ; Ghamande, Shekhar ; Herrick, Judy ; Hoffman, Eric ; Hughes, Kailey ; Lamerato, Lois E. ; Lauring, Adam S. ; McKillop, Amanda ; McNeal, Tresa ; McSpadden, E.J. ; Midturi, John ; Mutnal, Manohar ; Nowalk, Mary Patricia ; Petrie, Joshua G. ; Raiyani, Chandni ; Rao, Arundhati ; Saul, Sean G. ; Sax, Theresa M. ; Segaloff, Hannah E. ; Stiefel, Lori ; Volz, Marcus ; Walker, Kimberly ; Wheeler, Nicole ; White, Heath ; Williams, John V. ; Yassin, Mohamed ; Zayed, Martha ; Zunie, Tnelda
• Corporate Authors:
  IVY Network ; HAIVEN Investigators
• Description:
  Adults aged ≥65 years are at increased risk for severe outcomes from COVID-19 and were identified as a priority group to receive the first COVID-19 vaccines approved for use under an Emergency Use Authorization (EUA) in the United States (1-3). In an evaluation at 24 hospitals in 14 states,* the effectiveness of partial or full vaccination| with Pfizer-BioNTech or Moderna vaccines against COVID-19-associated hospitalization was assessed among adults aged ≥65 years. Among 417 hospitalized adults aged ≥65 years (including 187 case-patients and 230 controls), the median age was 73 years, 48% were female, 73% were non-Hispanic White, 17% were non-Hispanic Black, 6% were Hispanic, and 4% lived in a long-term care facility. Adjusted vaccine effectiveness (VE) against COVID-19-associated hospitalization among adults aged ≥65 years was estimated to be 94% (95% confidence interval [CI] = 49%-99%) for full vaccination and 64% (95% CI = 28%-82%) for partial vaccination. These findings are consistent with efficacy determined from clinical trials in the subgroup of adults aged ≥65 years (4,5). This multisite U.S. evaluation under real-world conditions suggests that vaccination provided protection against COVID-19-associated hospitalization among adults aged ≥65 years. Vaccination is a critical tool for reducing severe COVID-19 in groups at high risk.
• Subjects:
  Aged COVID-19 COVID-19 Vaccines Female Hospitalization Humans Male Risk Assessment Treatment Outcome Vaccination Coverage Vaccines, Synthetic

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 70(18):674-679
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7018e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  33956782
• Pubmed Central ID:
  PMC9368749
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  70
• Issue:
  18
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:4cf8f5f27cc33fd9c457accf9695a13c06a3e89161ab0f0c0ea5273c2b1598ae1c223eae3cea2d69930122d7ccb9887935951c80c44b3f884ebec0f040e9633e
• Download URL:
  https://stacks.cdc.gov/view/cdc/120627/cdc_120627_DS1.pdf
• File Type:
  [PDF - 134.59 KB ]