National inventory for poliovirus containment : minimizing risk of poliovirus release from laboratories in the United States
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National inventory for poliovirus containment : minimizing risk of poliovirus release from laboratories in the United States

Filetype[PDF-2.93 MB]


English
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  • Corporate Authors:
    Center for Preparedness and Response (U.S.). Board of Scientific Counselors.
  • Description:
    The US Poliovirus National Authority for Containment of Poliovirus (NAC), located in the Centers for Disease Control and Prevention, Center for Preparedness and Response, appreciates your participation in this survey. This survey is designed to collect relevant laboratory inventory data to ensure compliance with requirements established in the WHO Global Action Plan (GAPIII)external icon, as adapted for the WHO Region of the Americas. PerGAPIII, each country is required to complete a national inventory of poliovirus-containing materials. Unlike previous surveys, the 2018 survey focuses on institutions that may have poliovirus potentially infectious materials (PIM). PIM includes human respiratory secretion and fecal specimens collected for non-polio related work in a time and place where wild poliovirus (WPV) or vaccine-derived poliovirus (cVDPV) was circulating or where oral polio vaccine (OPV) was in use. Historical domestic and international specimens are more likely to fall into these categories. Additionally, PIM cultured in some common cell lines (see Appendix C: Common Cell Lines and Animals Susceptible to Poliovirus) in order to isolate other viruses of interest may have unintentionally amplified poliovirus, so respiratory or enteric viral isolates obtained from PIM specimens using any of these cell lines are also considered PIM.

    The survey should be completed by laboratories, storage sites, or other facility types that test, extract, handle, or store biological samples from humans, experimentally infected animals, sewage, or environmental waters. The survey questions are intended to identify facilities that possess any materials that may contain poliovirus. The questions seek to distinguish between PIM containing wild poliovirus (WPV), circulating vaccine derived poliovirus (cVDPV), and oral poliovirus vaccine (OPV). With the release of the WHO PIM guidanceexternal icon in April 2018, extracted nucleic acid and specimens that may contain only OPV are no longer subject to containment under WHO GAP III. However, they are still considered to be part of the US inventory and should be reported.

  • Content Notes:
    Survey Overview -- Survey Instructions -- National Inventory for Poliovirus Containment Survey -- Appendices -- Appendix D -- Reference Documents.
  • Subjects:
  • Document Type:
    Webpage
  • Name as Subject:
  • Place as Subject:
    United States
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