Details:

Alternative Title:
Cancer Causes Control
Personal Author:
White, Mary C. ; Weir, Hannah K. ; Soman, Ashwini V. ; Peipins, Lucy A. ; Thompson, Trevor D.
White, Mary C. ; Weir, Hannah K. ; Soman, Ashwini V. ; Peipins, Lucy A. ; Thompson, Trevor D. Less -
Description:
Purpose

Women exposed to diethylstilbestrol (DES) in utero were at elevated risk of clear-cell adenocarcinoma of the vagina and cervix (CCA) as young women. Previous research suggested that this elevated risk of CCA may persist into adulthood. We extended a published analysis to measure CCA risk as these women aged.

Methods

Standardized incidence ratios (SIR) compared CCA risk among women born from 1947 through 1971 (the DES-era) to CCA risk among the comparison group of women born prior to 1947, using registry data that covered the US population.

Results

Incidence rates of CCA among both cohorts increased with age. Among the DES-era birth cohort, higher rates of CCA were observed across all age groups except 55–59 years. SIR estimates had wide confidence intervals that often included the null value.

Conclusions

Results are consistent with prior research and suggest an elevated risk of CCA in midlife and at older ages among women exposed in utero to DES. These results highlight unresolved issues regarding cancer risk among aging DES daughters and appropriate screening guidance. The examination of population-based cancer surveillance data may be a useful tool for monitoring trends in the incidence of other rare cancers over time among specific birth cohorts.


Subjects:
[+]
Adenocarcinoma, Clear Cell Adult Article Cancer Registries Cancer Surveillance Cervix Uteri DES Diethylstilbestrol Female Gynecologic Cancer Humans Prenatal Exposure Prenatal Exposure Delayed Effects Uterine Cervical Neoplasms Vagina Vaginal Neoplasms
Source:
Cancer Causes Control. 33(8):1121-1124
Pubmed ID:
35767133
Pubmed Central ID:
PMC9377316
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; HHSN31620120007W 200-2017-F-94805/CC/CDC HHSUnited States/
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; HHSN31620120007W 200-2017-F-94805/CC/CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c0b2cb4a70228ff5ef5370cbf77d9c4bf067c2cf028c52c1e572838448205fd8
Download URL:
https://stacks.cdc.gov/view/cdc/120300/cdc_120300_DS1.pdf
File Type:

Supporting Files

• 	nihms-1820146.nxml	xml
  	NIHMS1820146-supplement-Supplementary_Figure_1.pdf	pdf

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