A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  Cardiovasc Diabetol
• Personal Author:
  Shah, Amy S. ; Isom, Scott ; Dabelea, Dana ; D’Agostino, Ralph ; Dolan, Lawrence M. ; Wagenknecht, Lynne ; Imperatore, Giuseppina ; Saydah, Sharon ; Liese, Angela D. ; Lawrence, Jean M. ; Pihoker, Cate ; Urbina, Elaine M.
• Corporate Authors:
  SEARCH for Diabetes in Youth Study Group
• Description:
  Aims
  
  To compare left ventricular structure (LV) and diastolic function in young adults with youth- onset diabetes by type, determine the prevalence of abnormal diastolic function by diabetes type using published values from age similar healthy controls, and examine the risk factors associated with diastolic function.
  
  Methods
  
  In a cross sectional analysis we compared LV structure and diastolic function from two dimensional echocardiogram in participants with type 1 (T1D) and type 2 diabetes (T2D) who participated in the SEARCH for Diabetes in Youth Study. Linear models were used to examine the risk factors associated with worse diastolic function.
  
  Results
  
  Of 479 participants studied, 258 had T1D (mean age 21.2 ± 5.2 years, 60.5% non-Hispanic white, 53.9% female) and 221 had T2D (mean age 24.8 ± 4.3 years, 24.4% non-Hispanic white, 73.8% female). Median diabetes duration was 11.6 years. Participants with T2D had greater LV mass index and worse diastolic function that persisted after adjustment for differences in risk factors compared with participants with T1D (all p < 0.05). Abnormal diastolic function, quantified using healthy controls, was pronounced in both groups but greater in those with T2D than T1D (T2D: 57.7% vs T1D: 47.2%, respectively), p < 0.05. Risk factors associated with worse diastolic function included older age at diabetes diagnosis, female sex, higher BP, heart rate and HbA1c and longer diabetes duration.
  
  Conclusions
  
  LV structure and diastolic function is worse in individuals with T2D compared to T1D. However, abnormal diastolic function in seen in both groups compared to published values from age similar healthy controls.
  
  Supplementary Information
  
  The online version contains supplementary material available at 10.1186/s12933-021-01328-0.
  
  
• Subjects:
  Adolescent Adult Age Of Onset Case-Control Studies Cross-Sectional Studies Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diastole Echocardiography Female Humans Hypertrophy, Left Ventricular Male Predictive Value Of Tests Prevalence Risk Assessment Risk Factors Ventricular Dysfunction, Left Ventricular Function, Left Ventricular Remodeling Young Adult

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• Source:
  Cardiovasc Diabetol. 20
• Pubmed ID:
  34233679
• Pubmed Central ID:
  PMC8265135
• Document Type:
  Journal Article
• Funding:
  U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006138/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006131/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006134/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK127208/DK/NIDDK NIH HHSUnited States/ ; UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; U18 DP006133/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  20
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b7f99906674b45c61cd9eb3d172ec594fa183d9ada1265f075efc62fc21f7c9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/119602/cdc_119602_DS1.pdf
• File Type:
  [PDF - 893.52 KB ]