Chronic medical conditions and late effects following non-Hodgkin lymphoma in HIV-uninfected and HIV-infected adolescents and young adults: a population-based study

Details

• Alternative Title:
  Br J Haematol
• Personal Author:
  Abrahão, Renata ; Li, Qian W. ; Malogolowkin, Marcio H. ; Alvarez, Elysia M. ; Ribeiro, Raul C. ; Wun, Ted ; Keegan, Theresa H. M.
• Description:
  Little is known about the incidence of late effects following non-Hodgkin lymphoma (NHL) among adolescent and young adult (AYA, 15-39 years) survivors. Using data from the California Cancer Registry linked to hospital discharge, we estimated the cumulative incidence of late effects at 10 years among AYAs diagnosed with NHL during 1996-2012, who survived ≥2 years. Cox proportional-hazards models were used to investigate the influence of sociodemographic and clinical factors on the occurrence of late effects. Of 4392 HIV-uninfected patients, the highest incident diseases were: endocrine (18·5%), cardiovascular (11·7%), and respiratory (5·0%), followed by secondary primary malignancy (SPM, 2·6%), renal and neurologic (2·2%), liver/pancreatic (2·0%), and avascular necrosis (1·2%). Among the 425 HIV-infected survivors, incidence was higher for all late effects, especially over threefold increased risk of SPM, compared to HIV-uninfected patients (8·1% vs. 2·6%). In multivariable models for HIV-uninfected patients, public or no health insurance (vs. private), residence in lower socioeconomic neighbourhoods (vs. higher), and receipt of a haematopoietic stem cell transplant were associated with a greater risk of most late effects. Our findings of substantial incidence of late effects among NHL AYA survivors emphasise the need for longterm follow-up and appropriate survivorship care to reduce morbidity and mortality in this vulnerable population.
• Subjects:
  Adolescent Adult Cancer Survivors Cardiovascular Diseases Chronic Disease Digestive System Diseases Endocrine System Diseases Female Humans Incidence Kidney Diseases Lymphoma, AIDS-Related Lymphoma, Non-Hodgkin Neoplasms, Second Primary Nervous System Diseases Proportional Hazards Models Registries Respiratory Tract Diseases Socioeconomic Factors Young Adult

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• Source:
  Br J Haematol. 190(3):371-384
• Pubmed ID:
  32080836
• Pubmed Central ID:
  PMC9245545
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; UL1 0000860/National Center for Advancing Translational Science (NCATS), NIH/ ; T32HP300370401/National Research Service Award (NRSA) for Primary Medical Care/ ; 5NU58DP006344/Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries/ ; Rich and Weissman Family Lymphoma and Survivorship Fund St. Baldrick's Research Grant/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001860/TR/NCATS NIH HHSUnited States/ ; the California Department of Public Health pursuant to California Health and Safety Code Section 103885/ ; HHSN261201000035C/PC/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/
• Volume:
  190
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c7b35dad3cec42da5f43dbfb4f342ce1820052f6332a27354cf999bc53ebca38
• Download URL:
  https://stacks.cdc.gov/view/cdc/119338/cdc_119338_DS1.pdf
• File Type:
  [PDF - 476.20 KB ]