Immunobiology of Crimean-Congo hemorrhagic fever

Details

• Alternative Title:
  Antiviral Res
• Personal Author:
  Rodriguez, Sergio E. ; Hawman, David W. ; Sorvillo, Teresa E. ; O’Neal, T. Justin ; Bird, Brian H. ; Rodriguez, Luis L. ; Bergeron, Éric ; Nichol, Stuart T. ; Montgomery, Joel M. ; Spiropoulou, Christina F. ; Spengler, Jessica R.
• Description:
  Human infection with Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne pathogen in the family Nairoviridae, can result in a spectrum of outcomes, ranging from asymptomatic infection through mild clinical signs to severe or fatal disease. Studies of CCHFV immunobiology have investigated the relationship between innate and adaptive immune responses with disease severity, attempting to elucidate factors associated with differential outcomes. In this article, we begin by highlighting unanswered questions, then review current efforts to answer them. We discuss in detail current clinical studies and research in laboratory animals on CCHF, including immune targets of infection and adaptive and innate immune responses. We summarize data about the role of the immune response in natural infections of animals and humans and experimental studies in vitro and in vivo and from evaluating immune-based therapies and vaccines, and present recommendations for future research.
• Subjects:
  Animals Hemorrhagic Fever, Crimean Hemorrhagic Fever Virus, Crimean-Congo Ticks
• Source:
  Antiviral Res. 199:105244
• Pubmed ID:
  35026307
• Pubmed Central ID:
  PMC9245446
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI151006/AI/NIAID NIH HHSUnited States/
• Volume:
  199
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:811ae7c808df924ccaa76b8243e019c9ef1fd637d24d33abc8b6a455d055a1cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/119337/cdc_119337_DS1.pdf
• File Type:
  [PDF - 967.81 KB ]