CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Immunobiology of Crimean-Congo hemorrhagic fever
-
3 2022
-
-
Source: Antiviral Res. 199:105244
[PDF-967.81 KB]
Details:
-
Alternative Title:Antiviral Res
-
Personal Author:
-
Description:Human infection with Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne pathogen in the family Nairoviridae, can result in a spectrum of outcomes, ranging from asymptomatic infection through mild clinical signs to severe or fatal disease. Studies of CCHFV immunobiology have investigated the relationship between innate and adaptive immune responses with disease severity, attempting to elucidate factors associated with differential outcomes. In this article, we begin by highlighting unanswered questions, then review current efforts to answer them. We discuss in detail current clinical studies and research in laboratory animals on CCHF, including immune targets of infection and adaptive and innate immune responses. We summarize data about the role of the immune response in natural infections of animals and humans and experimental studies in vitro and in vivo and from evaluating immune-based therapies and vaccines, and present recommendations for future research.
-
Subjects:
-
Source:
-
Pubmed ID:35026307
-
Pubmed Central ID:PMC9245446
-
Document Type:
-
Funding:
-
Volume:199
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
