Impact of isometric and concentric resistance exercise on pain and fatigue in fibromyalgia

Details

• Alternative Title:
  Eur J Appl Physiol
• Personal Author:
  Berardi, Giovanni ; Senefeld, Jonathon W ; Hunter, Sandra K ; Bement, Marie K. Hoeger
• Description:
  Purpose:
  
  The aim of this study was to determine the local and systemic effects of isometric and concentric muscle contractions on experimental pain and performance fatigability in people with and without fibromyalgia.
  
  Methods:
  
  Forty-seven fibromyalgia (FM:51.3±12.3yr) and forty-seven control (CON:52.5±14.7yr) participants performed submaximal isometric and concentric exercise for ten minutes with the right elbow flexors. Assessments before and after exercise included pressure pain thresholds (PPT) of the biceps and quadriceps, central pain summation, self-reported exercising arm and whole-body pain, and maximal voluntary isometric contraction (MVIC) of the right elbow flexors and left handgrip.
  
  Results:
  
  People with FM experienced greater reductions in local fatigue (right elbow flexor MVIC: CON:−4.0±6.7%, FM:−9.8±13.8%; p=0.013) and similar reductions in systemic fatigue (left handgrip MVIC:−6.5±10.2%; p<0.001) as CON participants, which were not different by contraction type nor related to baseline clinical pain, perceived fatigue, or reported pain with exercise. Following exercise both groups reported an increase in PPTs at the biceps (pre:205.5±100.3kPa, post:219.0±109.3kPa, p=0.004) only and a decrease in central pain summation (pre:6.8±2.9, post:6.5±2.9; p=0.013). FM reported greater exercising arm pain following exercise (CON:0.7±1.3, FM:2.9±2.3; p<0.001), and both groups reported greater arm pain following concentric (isometric:1.4±2.0, concentric:2.2±2.9; p=0.001) than isometric exercise. Neither group reported an increase in whole-body pain following exercise.
  
  Conclusion:
  
  People with FM experienced greater performance fatigability in the exercising muscle compared to CON that was not related to central mechanisms of fatigue or pain. These results suggest changes in performance fatigability in FM may be due to differences occurring at the muscular level.
  
  
• Subjects:
  Adult Aged Case-Control Studies Female Fibromyalgia Hand Strength Humans Isometric Contraction Male Middle Aged Muscle Contraction Muscle Fatigue Pain Measurement Resistance Training

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• Source:
  Eur J Appl Physiol. 121(5):1389-1404
• Pubmed ID:
  33616753
• Pubmed Central ID:
  PMC8076092
• Document Type:
  Journal Article
• Funding:
  TL1 TR001437/TR/NCATS NIH HHSUnited States/ ; U01 CE002944/CE/NCIPC CDC HHSUnited States/ ; U01 NS088034/NS/NINDS NIH HHSUnited States/ ; PODS-I/Foundation for Physical Therapy Research/ ; TL1TR001437/TR/NCATS NIH HHSUnited States/ ; R15HD090265/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; R15 HD090265/HD/NICHD NIH HHSUnited States/
• Volume:
  121
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b0bf4c9f7b6932e390c8d37dfbc9705ab822a82a9d6ad23da69be2d37fddc5c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/119171/cdc_119171_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]