Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, U.S. May 17–June 30, 2022

Details

• Personal Author:
  Aden, Tricia A. ; Blevins, Patricia ; York, Shannon Whitman ; Rager, Stacy ; Balachandran, Devika ; Hutson, Christina L. ; Lowe, David ; Mangal, Chris N. ; Wolford, Tyler ; Matheny, Audrey ; Davidson, Whitni ; Wilkins, Kimberly ; Cook, Rachael ; Roulo, Rebecca M. ; White, Michael K. ; Berman, LaShondra ; Murray, Janna ; Laurance, John ; Francis, Drew ; Green, Nicole M. ; Berumen, Ricardo A. ; Gonzalez, Anthony ; Evans, Stacy ; Hudziec, Meghan ; Noel, Diane ; Adjei, Michael ; Hovan, Gregory ; Lee, Phil ; Tate, Lisa ; Gose, Remedios B. ; Voermans, Robert ; Crew, Jennifer ; Adam, Phillip R. ; Haydel, Danielle ; Lukula, Salimatu ; Matluk, Nick ; Shah, Sandip ; Featherston, Joshua ; Ware, Daphne ; Pettit, Denise ; McCutchen, Emily ; Acheampong, Edward ; Buttery, Erin ; Gorzalski, Andrew ; Perry, Michael ; Fowler, Randal ; Lee, Robert B. ; Nickla, Robert ; Huard, Richard ; Moore, Amanda ; Jones, Katie ; Johnson, Renee ; Swaney, Erin ; Jaramillo, Juan ; Webb, Cynthia Reinoso ; Guin, Brandon ; Yost, Janine ; Atkinson, Annette ; Griffin-Thomas, Latoya ; Chenette, Jessica ; Gant, Jessica ; Sterkel, Alana ; Ghuman, Harjinder K. ; Lute, James ; Smole, Sandra C. ; Arora, Vaneet ; Demontigny, Courtney K. ; Bielby, Meilan ; Geeter, Evelyn ; Newman, Kimberly A. M. ; Glazier, Mark ; Lutkemeier, Whitney ; Nelson, Megan ; Martinez, Raymond ; Chaitram, Jasmine ; Honein, Margaret A. ; Villanueva, Julie M.
• Corporate Authors:
  National Center for Emerging and Zoonotic Infectious Diseases (U.S.) ; Div. of Preparedness and Emerging Infections ; Deloitte Consulting, LLP, Atlanta, Georgia ; National Center for Emerging and Zoonotic Infectious Disease (U.S.) ; Div. of High-Consequence Pathogens and Pathology ; Association of Public Health Laboratories ; St. John Group Atlanta, GA ; Alaska State Public Health Laboratory ; Arizona State Public Health Laboratory ; Los Angeles County, CA Public Health Laboratory ; California Dept. of Public Health Laboratory ; Sacramento County Public Health Laboratory ; San Luis Obispo County, CA Public Health Dept., San Luis Obispo, California ; Colorado Dept. of Public Health & Environment ; Connecticut Dept. of Public Health ; Dr. Katherine A. Kelley Public Health Laboratory ; District of Columbia Public Health Laboratory ; Delaware Public Health Laboratory ; Florida Bureau of Public Health Laboratories-Jacksonville, Jacksonville, Florida ; Florida Bureau of Public Health Laboratories-Tampa, Tampa, Florida ; Hawaii State Laboratories Div. ; Idaho Bureau of Laboratories ; Chicago, IL. Dept. of Public Health Laboratory ; Kansas Health & Environmental Laboratories ; Louisiana Public Health Laboratory ; Maryland Laboratories Administration ; Maine State Health and Environmental Testing Laboratory ; Michigan Public Health Laboratory ; Missouri State Public Health Laboratory ; Mississippi Public Health Laboratory ; North Carolina State Laboratory of Public Health ; Nebraska Public Health Laboratory ; New Jersey Div. of Public Health & Environmental Laboratories ; Southern Nevada Public Health Laboratory ; Nevada State Public Health Laboratory ; New York State Dept. of Health Wadsworth Center ; New York, NY Dept. of Health and Mental Hygiene Bureau of Laboratories ; Ohio Dept. of Health Laboratories ; Oregon State Public Health Laboratory ; Rhode Island State Health Laboratories ; South Carolina Bureau of Laboratories ; Knoxville Regional Public Health Laboratory ; Tennessee Dept. of Health: Laboratory Services ; Texas Dept. of State Health Services ; Dallas County Health and Human Services ; Texas Tech University Bioterrorism Response Laboratory ; San Antonio Metro Health District Laboratory. ; Public Health Laboratory of East Texas (Tyler, Texas) ; Unified Utah State Laboratories Public Health ; Virginia Div. of Consolidated Laboratory Services ; Vermont Dept. of Health Laboratory ; Washington Public Health Laboratories ; Wisconsin State Laboratory of Hygiene ; Georgia Public Health Laboratory ; Pennsylvania Bureau of Laboratories ; MassachU.S.etts State Public Health Laboratory ; Kentucky Div. of Laboratory Service ; Minnesota Public Health Laboratory Div. ; HoU.S.ton Public Health Laboratory HoU.S.ton, TX ; Alabama Bureau of Clinical Laboratories ; Montana Laboratory Services Bureau ; Indiana Public Health Laboratory ; South Dakota Public Health Laboratory ; University of Iowa State Hygienic Laboratory ; CorpU.S. Christi – Nueces County Health Dept. Laboratory CorpU.S. Christi, TX ; Center for Surveillance, Epidemiology, and Laboratory Services (U.S.) ; Div. of Laboratory Systems
• Description:
  What is already known on this topic? The Laboratory Response Network (LRN) includes U.S. laboratories validated to perform the non-variola OrthopoxVirus (NVO) assay.
  
  What is added by this report? During May 17–June 30, 2022, LRN laboratories tested 2,009 specimens from patients with suspected monkeypox. Among these, 730 (36%) specimens from 395 patients were positive for NVO. Specimens from 159 persons with NVO-positive results were confirmed by CDC to be monkeypox; confirmatory tTesting is pending for 236. LRN laboratories have increased tTesting capacity from 8,000 per week in June because of NVO assay updates.
  
  What are the implications for public health practice? LRN laboratories’ rapid results enable prompt patient treatment and Prevention of further Transmission. Expansion of tTesting to five large national laboratories will increase ease of access to tTesting.
  
  As part of public health preparedness for infectious disease threats, CDC collaborates with other U.S. public health officials to ensure that the Laboratory Response Network (LRN) has diagnostic tools to detect OrthopoxViruses, the genus that includes Variola Virus, the causative agent of smallpox. LRN is a network of state and local public health, federal, U.S. Department of Defense (DOD), Veterinary, food, and environmental tTesting Laboratories CDC developed, and the Food and Drug Administration (FDA) granted 510(k) clearance* for the Non-variola OrthopoxVirus Real-time PCR Primer and Probe Set (non-variola OrthopoxVirus [NVO] assay), a polymerase chain reaction (PCR) diagnostic test to detect NVO. On May 17, 2022, CDC was contacted by the Massachusetts Department of Public Health (DPH) regarding a suspected case of monkeypox, a disease caused by the OrthopoxVirus Monkeypox Virus. Specimens were collected and tested by the Massachusetts DPH public health laboratory with LRN tTesting capability using the NVO assay. Nationwide, 68 LRN laboratories had capacity to test approximately 8,000 NVO tests per week during June. During May 17–June 30, LRN laboratories tested 2,009 specimens from suspected monkeypox cases. Among those, 730 (36.3%) specimens from 395 patients were positive for NVO. NVO-positive specimens from 159 persons were confirmed by CDC to be monkeypox; final characterization is pending for 236. Prompt identification of persons with infection allowed rapid response to the outbreak, including isolation and treatment of patients, administration of vaccines, and other public health action. To further facilitate access to tTesting and increase convenience for providers and patients by using existing provider-laboratory relationships, CDC and LRN are supporting five large commercial laboratories with a national footprint (Aegis Science, LabCorp, Mayo Clinic Laboratories, Quest Diagnostics, and Sonic Healthcare) to establish NVO tTesting capacity of 10,000 specimens per week per laboratory. On July 6, 2022, the first commercial laboratory began accepting specimens for NVO tTesting based on clinician orders.
  
  Suggested citation for this article: Aden TA, Blevins P, York SW, et al. Rapid Diagnostic Testing for Response to the Monkeypox Outbreak — Laboratory Response Network, U.S. May 17–June 30, 2022. MMWR Morb Mortal Wkly Rep. ePub: 8 July 2022.
  
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  mm7128e1-H.pdf
  
  
• Subjects:
  Diagnostic Tests, Routine Disease Outbreaks/Prevention & Control Laboratories Molecular Diagnostic Techniques Mpox (monkeypox)/Diagnosis Public Health
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  4 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:0a6f200f77e8bf70289a32ca9903ee5bbd517f993a2c2782c029add7e1cb3cd185c86d2b858c8a487e8e8b4476ee2bb7d2a3af774d59aa6e568d102ab4e4f9cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/118971/cdc_118971_DS1.pdf
• File Type:
  [PDF - 219.10 KB ]