Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men’s Correctional Facility, United States

Silverman, Rachel A.; Ceci, Alessandro; Cohen, Alasdair; Helmick, Meagan; Short, Erica; Bordwine, Paige; Friedlander, Michael J.; Finkielstein, Carla V.

doi:10.3201/eid2807.220091

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Vaccine Effectiveness during Outbreak of COVID-19 Alpha (B.1.1.7) Variant in Men’s Correctional Facility, United States

7 2022
By Silverman, Rachel A. ; Ceci, Alessandro ; Cohen, Alasdair ; ...
http://dx.doi.org/10.3201/eid2807.220091
Source: Emerg Infect Dis. 2022; 28(7):1321-1326

[PDF-548.71 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Silverman, Rachel A. ; Ceci, Alessandro ; Cohen, Alasdair ; Helmick, Meagan ; Short, Erica ; ... More +

Silverman, Rachel A. ; Ceci, Alessandro ; Cohen, Alasdair ; Helmick, Meagan ; Short, Erica ; Bordwine, Paige ; Friedlander, Michael J. ; Finkielstein, Carla V. Less -
Description:

In April 2021, a COVID-19 outbreak occurred at a correctional facility in rural Virginia, USA. Eighty-four infections were identified among 854 incarcerated persons by facilitywide testing with reverse transcription quantitative PCR (qRT-PCR). We used whole-genome sequencing to link all infections to 2 employees infected with the B.1.1.7α (UK) variant. The relative risk comparing unvaccinated to fully vaccinated persons (mRNA-1273 [Moderna, https://www.modernatx.com]) was 7.8 (95% CI 4.8-12.7), corresponding to a vaccine effectiveness of 87.1% (95% CI 79.0%-92.1%). Average qRT-PCR cycle threshold values were lower, suggesting higher viral loads, among unvaccinated infected than vaccinated cases for the nucleocapsid, envelope, and spike genes. Vaccination was highly effective at preventing SARS-CoV-2 infection in this high-risk setting. This approach can be applied to similar settings to estimate vaccine effectiveness as variants emerge to guide public health strategies during the ongoing pandemic.
Subjects:

[+]

Correctional Facilities Covid-19 Disease Outbreaks Humans Male Sars-Cov-2 Vaccine Efficacy
Source:

Emerg Infect Dis. 2022; 28(7):1321-1326
Pubmed ID:

35731137
Pubmed Central ID:

PMC9239860
Document Type:

Journal Article
Place as Subject:

United States
Volume:

28
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:fc06ce929488e02bad4be4a488aa89de616aed23fbe1411f77b904f0e3631ad6
Download URL:

https://stacks.cdc.gov/view/cdc/118928/cdc_118928_DS1.pdf
File Type:

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