Supporting a Neuroimmune Basis of Gulf War Illness

Details

• Journal Article:
  EBioMedicine
• Personal Author:
  O'Callaghan, James P. ; Michalovicz, Lindsay T. ; Kelly, Kimberly A.
• Description:
  Gulf War Illness (GWI) is a complex multi-symptom disorder that has proven elusive to understand and treat and it afflicts as many as a quarter of the 700,000 soldiers deployed (Steele, 2000) to the Persian Gulf in the 1991 war. These ill veterans were exposed to a number of agents and conditions, but no specific sets of exposures can explain the persistent symptoms (e.g. headaches, chronic fatigue, memory loss, confusion, skin and gastrointestinal problems) and, not surprisingly, the pathophysiology of GWI has remained unclear (RAC, 2008). However, recent examinations of ill veterans reveal a systemic immune dysfunction that is exacerbated by physiological stress (Broderick et al., 2013). Congruently, animal models nowexist that point to a heightened neuroinflammation resulting from several Gulf War-relevant chemical and physiological exposures (O'Callaghan et al., 2015). Neuroinflammation, the elaboration of proinflammatory cytokines and chemokines in the CNS, is known to serve as an underlying cause of sickness behavior, the features of which resemble those associated with GWI. Thus, a convergence of animal and human data now point to a neuroimmune mechanism underlying this disease. [Description provided by NIOSH]
• Subjects:
  Animals Behavior Chemistry Environmental Exposure Gulf War Immune System Immunity Laboratories Nervous System Nervous System Diseases Occupational Health Persian Gulf Syndrome Risk Assessment Risk Factors Safety

  More +
• Keywords:
  Military personnel; Humans; Men; Women; Exposure levels; Risk factors; Physiological stress; Physiological effects; Physiology; Animals; Laboratory animals; Models; Stress; Chemical reactions; Chemical properties; Chemical deposition; Chemicals; Cytokines; Behavior; Neurological diseases; Neurological disorders; Neurological reactions; Neurological system
• Source:
  EBioMedicine 2016 Nov; 13:5-6
• ISSN:
  2352-3964
• Pubmed ID:
  27806904
• Pubmed Central ID:
  PMC5264477
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  2 pdf pages
• Volume:
  13
• NIOSHTIC Number:
  nn:20049084
• Contact Point Address:
  James P. O'Callaghan, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Rd, Morgantown, WV 26505
• Email:
  jdo5@cdc.gov
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:aa285ce312bb5ace45b7deabde31bd1b4385b3de9ec60a788e95a4a147dcec6997c44bad0a8ce5623d8662e313b3f41cef5271f3fb52c5f6fd24133f467c079f
• Download URL:
  https://stacks.cdc.gov/view/cdc/118758/cdc_118758_DS1.pdf
• File Type:
  [PDF - 144.75 KB ]