Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Rao, Agam K. ; Petersen, Brett W. ; Whitehill, Florence ; Razeq, Jafar H. ; Isaacs, Stuart N. ; Merchlinsky, Michael J. ; Campos-Outcalt, Doug ; Morgan, Rebecca L. ; Damon, Inger ; Sánchez, Pablo J. ; Bell, Beth P.
• Corporate Authors:
  United States. Advisory Committee on Immunization Practices.
• Description:
  Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices (ACIP) has continued to recommend preexposure vaccination for these persons since 1980 (1), when smallpox was eradicated (2). In 2015, ACIP made recommendations for the use of ACAM2000, the only orthopoxvirus vaccine available in the United States at that time (3). During 2020-2021, ACIP considered evidence for use of JYNNEOS, a replication-deficient Vaccinia virus vaccine, as an alternative to ACAM2000. In November 2021, ACIP unanimously voted in favor of JYNNEOS as an alternative to ACAM2000 for primary vaccination and booster doses. With these recommendations for use of JYNNEOS, two vaccines (ACAM2000 and JYNNEOS) are now available and recommended for preexposure prophylaxis against orthopoxvirus infection among persons at risk for such exposures.
• Subjects:
  Advisory Committees Animals Humans Immunization Mpox (monkeypox) Occupational Exposure Orthopoxvirus Smallpox Vaccination Vaccines Vaccinia Virus

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 71(22):734-742
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm7122e1
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  35653347
• Pubmed Central ID:
  PMC9169520
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  9 pdf pages
• Volume:
  71
• Issue:
  22
• Collection(s):
  Advisory Committee on Immunization Practices (ACIP) Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:14db5b68712a0416e4836a4ee0f861c2c048c80cb2a3a0a6af6afa9895fcb55946bd0d03884649b0d22c72d13f994c9cb853b4535d3bab16768ec911ce435f91
• Download URL:
  https://stacks.cdc.gov/view/cdc/118558/cdc_118558_DS1.pdf
• File Type:
  [PDF - 289.98 KB ]