Maternal prepregnancy weight and gestational weight gain in association with autism and developmental disorders in offspring

Details

• Alternative Title:
  Obesity (Silver Spring)
• Personal Author:
  Matias, Susana L. ; Pearl, Michelle ; Lyall, Kristen ; Croen, Lisa A. ; Kral, Tanja V. E. ; Fallin, Daniele ; Lee, Li-Ching ; Bradley, Chyrise B. ; Schieve, Laura A. ; Windham, Gayle C.
• Description:
  Objective:
  
  Maternal prepregnancy BMI and gestational weight gain (GWG) are examined in relation to autism spectrum disorder (ASD) and other developmental disorders (DD) in offspring in a multisite case-control study.
  
  Methods:
  
  Maternal prepregnancy BMI, obtained from medical records or self-report, was categorized as underweight, normal weight, overweight, obesity Class 1, or obesity Class 2/3. GWG was standardized for gestational age (GWG z score), and the rate (pounds/week) was categorized per adherence with clinical recommendations. Logistic regression models, adjusting for demographic factors, were used to assess associations with ASD (n = 1,159) and DD (n = 1,617), versus control children (n = 1,633).
  
  Results:
  
  Maternal obesity Class 2/3 was associated with ASD (adjusted odds ratio [AOR] = 1.87, 95% CI: 1.40–2.51) and DD (AOR = 1.61, 95% CI: 1.22–2.13). GWG z score was not associated with DD (AOR = 1.14, 95% CI: 0.95–1.36), but the GWG z score highest tertile was associated with higher odds of ASD, particularly among male children (AOR = 1.47, 95% CI: 1.15–1.88).
  
  Conclusions:
  
  Results indicate that maternal prepregnancy severe obesity increases risk of ASD and DD in children and suggest high gestational-age-adjusted GWG is a risk factor for ASD in male children. Because maternal BMI and GWG are routinely measured and potentially modifiable, these findings could inform early interventions for high-risk mother-child dyads.
  
  
• Subjects:
  Article Autism Spectrum Disorder Autistic Disorder Body Mass Index Case-Control Studies Child Developmental Disabilities Female Gestational Weight Gain Humans Male Overweight Pregnancy Weight Gain

  More +
• Source:
  Obesity (Silver Spring). 29(9):1554-1564
• Pubmed ID:
  34347372
• Pubmed Central ID:
  PMC9186321
• Document Type:
  Journal Article
• Funding:
  U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; U010DD00746/CC/CDC HHSUnited States/ ; U10DD000184/CC/CDC HHSUnited States/ ; U01 DD000746/DD/NCBDD CDC HHSUnited States/ ; U010DD00750/CC/CDC HHSUnited States/ ; U10DD000182/CC/CDC HHSUnited States/ ; U10DD000498/CC/CDC HHSUnited States/ ; U10 DD000901/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U10DD000183/CC/CDC HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; U10DD000901/CC/CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01DD000746/ACL/ACL HHSUnited States/ ; U010DD00748/CC/CDC HHSUnited States/ ; U010DD00749/CC/CDC HHSUnited States/ ; U10DD000181/CC/CDC HHSUnited States/ ; U01 DD000749/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD000752/DD/NCBDD CDC HHSUnited States/ ; U01 DD000750/DD/NCBDD CDC HHSUnited States/ ; U10DD000180/CC/CDC HHSUnited States/ ; U01DD000750/ACL/ACL HHSUnited States/ ; U01 DD000748/DD/NCBDD CDC HHSUnited States/ ; U010DD00752/CC/CDC HHSUnited States/
• Volume:
  29
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:075cf33e6738d7c9c51acfc2a2ef9a8cfcb2ddfa00dad9ba7f57b8bf2f411dfe
• Download URL:
  https://stacks.cdc.gov/view/cdc/118210/cdc_118210_DS1.pdf
• File Type:
  [PDF - 434.04 KB ]