Adverse Perinatal Outcomes Before and After Diagnosis with Systemic Lupus Erythematosus Among African American Women

Details

• Alternative Title:
  Arthritis Care Res (Hoboken)
• Personal Author:
  Angley, Meghan ; Drews-Botsch, Carolyn ; Lewis, Tené T. ; Badell, Martina ; Lim, S. Sam ; Howards, Penelope P. ; Angley, Meghan ; Drews-Botsch, Carolyn ; Lewis, Tené T. ; Badell, Martina ; Lim, S. Sam ; Howards, Penelope P.
• Description:
  Objective:
  
  Women with systemic lupus erythematosus (SLE) may experience adverse perinatal outcomes in the years before an SLE diagnosis. Overall, there is limited research on perinatal outcomes among African American women with SLE.
  
  Methods:
  
  Women with SLE identified from the Georgia Lupus Registry and the Georgians Organized Against Lupus Cohort were linked with birth certificates by the Georgia Department of Public Health. Births were categorized into occurring more than 3 years before SLE diagnosis, 0-3 years before SLE diagnosis, 0-3 years after SLE diagnosis or more than 3 years after SLE diagnosis. Comparison births certificates to African American women in the same geographic area were obtained from the National Center for Health Statistics. We used log-risk models to compare the risk of preterm birth or small-for-gestational age among SLE births in each diagnosis timing category to the general population, adjusting for maternal age and education and parity.
  
  Results:
  
  Births to women with SLE were more likely to occur preterm 0-3 years before SLE diagnosis (risk ratio [RR]: 1.71, 95% confidence interval [CI]: 1.24, 2.35), 0-3 years after SLE diagnosis (RR: 2.29, 95% CI: 1.70, 3.09) and 3 or more years after diagnosis (RR: 2.83, 95% CI: 2.36, 3.38), but not 3 or more years before SLE diagnosis compared to the general population (RR: 1.03, 95% CI: 0.77, 1.38). Similar results were observed for small-for-gestational age births.
  
  Conclusion:
  
  Our analysis, conducted among African American women, demonstrates an increased risk of adverse perinatal outcomes even before a clinical diagnosis of SLE.
  
  
• Subjects:
  Black Or African American Female Humans Infant, Newborn Lupus Erythematosus, Systemic Odds Ratio Pregnancy Pregnancy Complications Pregnancy Outcome Registries
• Source:
  Arthritis Care Res (Hoboken). 74(6):904-911 ; Arthritis Care Res (Hoboken). 74(6):904-911
• Pubmed ID:
  34931482
• Pubmed Central ID:
  PMC9133027
• Document Type:
  Journal Article
• Funding:
  T32-HL-130025/GF/NIH HHSUnited States/ ; F31 AR078047/AR/NIAMS NIH HHSUnited States/ ; U01DP005119/ACL/ACL HHSUnited States/ ; CDC-RFA-DP08-806/CC/CDC HHSUnited States/ ; CDC-PA03022/CC/CDC HHSUnited States/ ; F31-AR-078047-02/GF/NIH HHSUnited States/ ; T32 HL130025/HL/NHLBI NIH HHSUnited States/ ; U01-DP-005119-Q5X/CC/CDC HHSUnited States/
• Volume:
  74
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b9ed9b10ff8f12b7ec9d60fae21b1b8835666cdaeeb6104f01dabf4b585b79e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/117909/cdc_117909_DS1.pdf
• File Type:
  [PDF - 250.39 KB ]