Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial

Details

• Alternative Title:
  Br J Nutr
• Personal Author:
  Wang, Linlin ; Mei, Zuguo ; Li, Hongtian ; Zhang, Yali ; Liu, Jianmeng ; Serdula, Mary K.
• Description:
  Concerns have been raised about the benefits of Fe-containing supplements on infant birth weight among women with normal/high Hb levels at baseline. Thus far, no clinical trials have examined whether the effects of prenatal Fe-containing supplements on birth weight vary by maternal Hb levels. We compared the effects of Fe-folic acid (IFA) or multiple micronutrients (MMN) with folic acid (FA) supplements on birth weight among pregnant women with mild/no anaemia or high Hb levels. A double-blind randomised controlled trial was conducted in 2006-2009. In total, 18 775 pregnant women with mild/no anaemia (145 g/l) baseline Hb levels, IFA and MMN supplements increased birth weight by 91·44 (95% CI 3·37, 179·51) g and 107·63 (95% CI 21·98, 193·28) g (P<0·05), respectively, compared with the FA group. No differences were found between the IFA and the MMN group, regardless of maternal Hb concentration. In conclusion, the effects of Fe-containing supplements on birth weight depended on baseline Hb concentrations. The Fe-containing supplements improved birth weight in women with very high Hb levels before 20 weeks of gestation.
• Subjects:
  Adult Anemia, Iron-Deficiency Birth Weight Dietary Supplements Double-Blind Method Female Ferrous Compounds Fetal Growth Retardation Hematinics Hemoglobins Humans Iron, Dietary Maternal Nutritional Physiological Phenomena Nutritional Status Pregnancy Pregnancy Complications Pregnancy Trimester, Second Risk Rural Health Severity Of Illness Index Young Adult

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• Source:
  Br J Nutr. 115(4):644-649
• Pubmed ID:
  26824731
• Pubmed Central ID:
  PMC9048118
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  China
• Volume:
  115
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:98eebd8b57edf816c446e38072c969bffce535981afd3dd069a7d0ddb7836b12
• Download URL:
  https://stacks.cdc.gov/view/cdc/116877/cdc_116877_DS1.pdf
• File Type:
  [PDF - 486.00 KB ]