Evaluation of urine pneumococcal antigen test performance among adults in Western Kenya☆

Details

• Alternative Title:
  Diagn Microbiol Infect Dis
• Personal Author:
  Hampton, Lee M. ; Bigogo, Godfrey ; Jagero, Geofrey ; da Gloria Carvalho, Maria ; Pimenta, Fabiana ; Junghae, Muthoni ; Breiman, Robert F. ; Whitney, Cynthia G. ; Feikin, Daniel R. ; Conklin, Laura M.
• Description:
  When used in an area of rural western Kenya, the BinaxNOW® urine antigen test had a sensitivity of 67% (95% Confidence Interval [CI]: 43-85%) among 21 adults ≥15 years old with acute respiratory illnesses and pneumococcal bacteremia and a specificity of 98% (95% CI: 96-99%) among 660 adults ≥15 years old without fever or cough. The specificity of the test was not significantly affected by pneumococcal colonization, regardless of patients' HIV status, age, or sex. Use of the pneumococcal urine antigen test in clinical assessments of adults in Africa with acute respiratory illness is a viable option regardless of whether a patient is colonized by pneumococci, even among HIV-infected adults, although the moderate sensitivity of the urine antigen test indicates that the test is probably best used clinically as part of a panel with other tests that can detect pneumococci.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Antigens Antigens, Bacterial Diagnostic Tests, Routine Female Humans Immunoassay Male Middle Aged Pneumococcal Infections Sensitivity And Specificity Young Adult

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• Source:
  Diagn Microbiol Infect Dis. 85(4):405-408
• Pubmed ID:
  27220607
• Pubmed Central ID:
  PMC9040033
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  Kenya
• Volume:
  85
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:55e7863a5b0eaff97282750b175997c2610a1d5b49d7426dab15856c5d3e2f54
• Download URL:
  https://stacks.cdc.gov/view/cdc/116868/cdc_116868_DS1.pdf
• File Type:
  [PDF - 311.92 KB ]