Effectiveness of COVID-19 MRNA Vaccination in Preventing COVID-19–associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection — U.S. June 2021–February 2022

Details

• Personal Author:
  Plumb, Ian D. ; Feldstein, Leora R. ; Barkley, Eric ; Posner, Alexander B. ; Bregman, Howard S. ; Hagen, Melissa Briggs ; Gerhart, Jacqueline L.
• Corporate Authors:
  National Center for Immunization and Respiratory Diseases (U.S.) ; Div. of Viral Diseases ; CDC COVID-19 Emergency Response Team ; Epic Systems Corporation
• Description:
  What is already known about this topic? Persons with previous SARS-CoV-2 infection have some protection against reinfection leading to hospitalization, but there is limited evidence regarding the additional benefit of vaccination among these persons. ; What is added by this report? Among persons with previous infection, COVID-19 mRNA vaccination provided protection against subsequent COVID-19–associated hospitalization. Estimated vaccine effectiveness against reinfection leading to hospitalization during the Omicron-predominant period was approximately 35% after dose 2, and 68% after a booster dose. ; What are the implications for public health practice? To prevent COVID-19–associated hospitalization, all eligible persons should stay up to date with vaccination, including those with previous SARS-CoV-2 infection. ; Suggested citation for this article: Suggested citation for this article: Plumb ID, Feldstein LR, Barkley E, et al. Effectiveness of COVID-19 mRNA Vaccination in Preventing COVID-19–Associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection — U.S. June 2021–February 2022. MMWR Morb Mortal Wkly Rep. ePub: 12 April 2022. ; mm7115e2.htm?s_cid=mm7115e2_w ; mm7115e2-H.pdf
• Subjects:
  • 2019-nCoV Vaccine mRNA-1273
  • BNT162 Vaccine
  • Adults
  • COVID-19 Vaccines
  • COVID-19/Prevention & Control
  • Hospitalization
  • SARS-CoV-2
  • Vaccination
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  71
• Download URL:
  https://stacks.cdc.gov/view/cdc/116190/cdc_116190_DS1.pdf
• File Type:
  [PDF - 363.69 KB]
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:19e194fb483b4ad12e8954ebc7c57907464228f5671e39ac14dbceb9879cdbe02283155179c236aa90824b52589e78710599bcb39075f3b6ec7b02a9db314dc7