Effectiveness of COVID-19 MRNA Vaccination in Preventing COVID-19–associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection — U.S. June 2021–February 2022

Details

• Personal Author:
  Plumb, Ian D. ; Feldstein, Leora R. ; Barkley, Eric ; Posner, Alexander B. ; Bregman, Howard S. ; Hagen, Melissa Briggs ; Gerhart, Jacqueline L.
• Corporate Authors:
  National Center for Immunization and Respiratory Diseases (U.S.) ; Div. of Viral Diseases ; CDC COVID-19 Emergency Response Team ; Epic Systems Corporation
• Description:
  What is already known about this topic? Persons with previous SARS-CoV-2 infection have some protection against reinfection leading to hospitalization, but there is limited evidence regarding the additional benefit of vaccination among these persons.
  
  What is added by this report? Among persons with previous infection, COVID-19 mRNA vaccination provided protection against subsequent COVID-19–associated hospitalization. Estimated vaccine effectiveness against reinfection leading to hospitalization during the Omicron-predominant period was approximately 35% after dose 2, and 68% after a booster dose.
  
  What are the implications for public health practice? To prevent COVID-19–associated hospitalization, all eligible persons should stay up to date with vaccination, including those with previous SARS-CoV-2 infection.
  
  Suggested citation for this article: Suggested citation for this article: Plumb ID, Feldstein LR, Barkley E, et al. Effectiveness of COVID-19 mRNA Vaccination in Preventing COVID-19–Associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection — U.S. June 2021–February 2022. MMWR Morb Mortal Wkly Rep. ePub: 12 April 2022.
  
  mm7115e2.htm?s_cid=mm7115e2_w
  
  mm7115e2-H.pdf
  
  
• Subjects:
  2019-nCoV Vaccine MRNA-1273 Adults BNT162 Vaccine COVID-19 Vaccines COVID-19/Prevention & Control Hospitalization SARS-CoV-2 Vaccination
• Source:
  MMWR: Morbidity and Mortality Weekly Report 2022; v. 71 Early Release
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  71
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:19e194fb483b4ad12e8954ebc7c57907464228f5671e39ac14dbceb9879cdbe02283155179c236aa90824b52589e78710599bcb39075f3b6ec7b02a9db314dc7
• Download URL:
  https://stacks.cdc.gov/view/cdc/116190/cdc_116190_DS1.pdf
• File Type:
  [PDF - 363.69 KB ]