Details:

Alternative Title:
Clin Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/cid/cix423
Personal Author:
Romero, Candice ; Tinoco, Yeny O. ; Loli, Sebastian ; Razuri, Hugo ; Soto, Giselle ; ... More +
Romero, Candice ; Tinoco, Yeny O. ; Loli, Sebastian ; Razuri, Hugo ; Soto, Giselle ; Silva, María ; Galvan, Patricia ; Kambhampati, Anita ; Parashar, Umesh D. ; Kasper, Matthew R. ; Bausch, Daniel G. ; Simons, Mark P. ; Lopman, Benjamin Less -
Description:
Background.

Data on norovirus epidemiology among all ages in community settings are scarce, especially from tropical settings.

Methods.

We implemented active surveillance in 297 households in Peru from October 2012 to August 2015 to assess the burden of diarrhea and acute gastroenteritis (AGE) due to norovirus in a lower-middle-income community. During period 1 (October 2012–May 2013), we used a “traditional” diarrhea case definition (≥3 loose/liquid stools within 24 hours). During period 2 (June 2013–August 2015), we used an expanded case definition of AGE (by adding ≥2 vomiting episodes without diarrhea or 1–2 vomiting episodes plus 1–2 loose/liquid stools within 24 hours). Stool samples were tested for norovirus by reverse-transcription polymerase chain reaction.

Results.

During period 1, overall diarrhea and norovirus-associated diarrhea incidence was 37.2/100 person-years (PY) (95% confidence interval [CI], 33.2–41.7) and 5.7/100 PY (95% CI, 3.9–8.1), respectively. During period 2, overall AGE and norovirus-associated AGE incidence was 51.8/100 PY (95% CI, 48.8–54.9) and 6.5/100 PY (95% CI, 5.4–7.8), respectively. In both periods, children aged <2 years had the highest incidence of norovirus. Vomiting without diarrhea occurred among norovirus cases in participants <15 years old, but with a higher proportion among children <2 years, accounting for 35% (7/20) of all cases in this age group. Noroviruses were identified in 7% (23/335) of controls free of gastroenteric symptoms.

Conclusions.

Norovirus was a significant cause of AGE in this community, especially among children <2 years of age. Inclusion of vomiting in the case definition resulted in a 20% improvement for detection of norovirus cases.


Subject:
[+]
Acute Gastroenteritis Adolescent Adult Article Caliciviridae Infections Child Child, Preschool Diarrhea Female Gastroenteritis Humans Incidence Infant Male Middle Aged Norovirus Peru Prospective Studies Vomiting Young Adult Incidence Norovirus
Source:
Clin Infect Dis. 65(5):833-839
Pubmed ID:
29017284
Pubmed Central ID:
PMC8991320
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/
Place as Subject:
Peru
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fcd6b8b22ac23f14a50f8337183177ff5947732ac1c8604324db9a1ce15c53e7
Download URL:
https://stacks.cdc.gov/view/cdc/116103/cdc_116103_DS1.pdf
File Type:

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