Discovery through clinical sequencing in oncology

Details

• Alternative Title:
  Nat Cancer
• Personal Author:
  Donoghue, Mark T.A. ; Schram, Alison M. ; Hyman, David M. ; Taylor, Barry S.
• Description:
  The molecular characterization of tumors now informs clinical cancer care for many patients. This advent of molecular oncology has been driven by the expanding number of therapeutic biomarkers that can predict sensitivity to both approved agents and investigational agents. Beyond its role in driving clinical-trial enrollments and guiding therapy in individual patients, large-scale clinical genomics in oncology also represents a rapidly expanding research resource for translational scientific discovery. Here we review the progress, opportunities, and challenges of scientific and translational discovery from prospective clinical genomic screening programs now routinely conducted for patients with cancer.
• Subjects:
  Article
• Source:
  Nat Cancer. 1(8):774-783
• Pubmed ID:
  35122052
• Pubmed Central ID:
  PMC8985175
• Document Type:
  Journal Article
• Funding:
  U54 OD020355/OD/NIH HHSUnited States/ ; U54 OD020355/CD/ODCDC CDC HHSUnited States/ ; R01 CA207244/CA/NCI NIH HHSUnited States/ ; P30 CA008748/CA/NCI NIH HHSUnited States/ ; R01 CA245069/CA/NCI NIH HHSUnited States/ ; R01 CA204749/CA/NCI NIH HHSUnited States/
• Volume:
  1
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:34afb47b67849e50257d9b94c3120cc3f0ebdc9f1c682080d4652d30cbae5abe
• Download URL:
  https://stacks.cdc.gov/view/cdc/116089/cdc_116089_DS1.pdf
• File Type:
  [PDF - 854.19 KB ]