Tumors induced in C3H/HeJ mice by coal tar neutral subfractions

Richards, Donald E.

doi:10.26616/NIOSHPUB80101

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Tumors induced in C3H/HeJ mice by coal tar neutral subfractions

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Alternative Title:

National Institute for Occupational Safety and Health recent accomplishments
Personal Author:

Richards, Donald E.
Corporate Authors:

National Institute for Occupational Safety and Health. Division of Biomedical and Behavioral Science. ; National Institute for Occupational Safety and Health. Division of Physical Sciences and Engineering.

National Institute for Occupational Safety and Health. Division of Biomedical and Behavioral Science. ; National Institute for Occupational Safety and Health. Division of Physical Sciences and Engineering. Less -
Description:

"The biologic activity of seven coal tar neutral subfractions derived from coke oven effluents was investigated. A solution of each subfraction was prepared in toluene (108883) at a concentration of 50 milligrams per milliliter. A 100 microliter volume of each solution, containing 5 milligrams of the test material, was applied twice weekly to the clipped interscapular area of mice for a maximum of 26 weeks. Controls were treated with toluene only. Mice were examined daily for evidence of systemic toxicity, mortality, and tumors. All surviving animals were sacrificed and autopsied 2 week after completion of treatment. Neoplasms developed in the interscapular skin area of some of the mice treated with four of the seven materials. Squamous cell papillomas were present in mice treated with subfractions 7, 9, and 13, and squamous cell carcinomas were observed in animals receiving subfractions 9 and 10. The two subfractions that induced squamous cell carcinomas were shown by gas chromatographic/mass spectrometric analyses to contain many 4- and 5- ring polynuclear aromatic hydrocarbons, some of which are known to be carcinogenic." - NIOSHTIC-2

NIOSHTIC no. 00094208

80-101.pdf?id=10.26616/NIOSHPUB80101
Subjects:

[+]

Carcinogens/toxicity Coal Tar/toxicity
Series:

NIOSH Numbered Publications
DOI:

https://doi.org/10.26616/NIOSHPUB80101
Document Type:

Report
Pages in Document:

v, 22 numbered pages
NIOSHTIC Number:

00094208
Resource Number:

DHEW (NIOSH) Publication No. 80-101
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

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urn:sha-512:bdfbf1d8f654a4fe17707435a90d5c769999aa1ba2c8b6454e76cb7962710446194b6f4736a44c3cc9ef89a7bf3fecab3eaa8ae23e2caa245b20ed7fa5447db6
Download URL:

https://stacks.cdc.gov/view/cdc/115984/cdc_115984_DS1.pdf
File Type:

[PDF-6.35 MB]