Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates

Details

• Alternative Title:
  Am J Primatol
• Personal Author:
  Shively, Carol A. ; Lacreuse, Agnès ; Frye, Brett M. ; Rothwell, Emily S. ; Moro, Manuel
• Description:
  Aging across the Primate Order is poorly understood because ages of individuals are often unknown, there is a dearth of aged animals available for study, and because aging is best characterized by longitudinal studies which are difficult to carry out in long-lived species. The human population is aging rapidly, and advanced age is a primary risk factor for several chronic diseases and conditions that impact healthspan. As lifespan has increased, diseases and disorders of the central nervous system (CNS) have become more prevalent, and Alzheimer's disease and related dementias have become epidemic. Nonhuman primate (NHP) models are key to understanding the aging primate CNS. This Special Issue presents a review of current knowledge about NHP CNS aging across the Primate Order. Similarities and differences to human aging, and their implications for the validity of NHP models of aging are considered. Topics include aging-related brain structure and function, neuropathologies, cognitive performance, social behavior and social network characteristics, and physical, sensory, and motor function. Challenges to primate CNS aging research are discussed. Together, this collection of articles demonstrates the value of studying aging in a breadth of NHP models to advance our understanding of human and nonhuman primate aging and healthspan.
• Subjects:
  Aging Animals Biology Chronic Disease Cognitive Dysfunction Primates United States
• Keywords:
  Aging Alzheimer’s Disease Cognitive Decline Gait Speed Nonhuman Primate
• Source:
  Am J Primatol. 83(11):e23309
• Pubmed ID:
  34403529
• Pubmed Central ID:
  PMC8935964
• Document Type:
  Journal Article
• Funding:
  P40 OD010965/OD/NIH HHSUnited States/ ; R01 AG046266/AG/NIA NIH HHSUnited States/ ; T32 AG033534/AG/NIA NIH HHSUnited States/ ; R24 AG073199/AG/NIA NIH HHSUnited States/ ; P30 AG21332/AG/NIA NIH HHSUnited States/ ; P30 AG021332/AG/NIA NIH HHSUnited States/ ; P40 OD010965/CD/ODCDC CDC HHSUnited States/ ; F32 AG064925/AG/NIA NIH HHSUnited States/ ; RF1 AG058829/AG/NIA NIH HHSUnited States/ ; P30 AG049638/AG/NIA NIH HHSUnited States/ ; UL1 TR001420/TR/NCATS NIH HHSUnited States/ ; UL1TR001420/TR/NCATS NIH HHSUnited States/
• Volume:
  83
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0021b79c17f4a5eb98dc260a6c682ac013e17772a02a40cb339c100a6cfb485a34d713f6d702c8c27d5fbf9ac0952396c1469e6ce790677e673a4d1b98e9999b
• Download URL:
  https://stacks.cdc.gov/view/cdc/115612/cdc_115612_DS1.pdf
• File Type:
  [PDF - 646.12 KB ]