E-Cigarette Aerosol Reduces Left Ventricular Function in Adolescent Mice

Details

• Journal Article:
  Circulation
• Personal Author:
  Neczypor, Evan W. ; Saldaña, Ty A. ; Mears, Matthew J. ; Aslaner, David M. ; Escobar, Yael-Natalie H. ; Gorr, Matthew W. ; Wold, Loren E.
• Description:
  Electronic cigarette (EC) use (vaping) has grown at an alarming rate in recent years. Originally used as a cessation aid for combustible cigarette smoking, vaping has grown exponentially in popularity in adolescents and teenagers. Although there are clear pulmonary consequences of EC use, adolescent cardiac health has not been examined despite the well-documented impact of particulate matter (found in EC aerosol) on the heart. Therefore, the cardiovascular system may encounter significant detriment after EC exposure throughout the sensitive period of adolescence. To investigate this, we used a mouse model of adolescent EC exposure. ... To our knowledge, this is the first study to evaluate cardiac function in adolescent mice exposed to EC aerosol. Our results heighten the concern for the dangers of EC use, specifically in youth, and call for further work detailing the mechanistic contributions to the observed cardiac dysfunction. Although EC aerosol alone appeared to have a more mild effect on cardiac function, a synergistic effect of nicotine and its metabolites with reactive by-products of combustion, such as various aldehydes, could account for the more pronounced consequences after nicotine exposure. Regardless, the novel results of this study demonstrate that EC aerosol exposure can reduce cardiac function in developing male mice. [Description provided by NIOSH]
• Subjects:
  Adolescent Aerosols Animals Biomarkers Cardiovascular Diseases Cardiovascular System Electrical Equipment And Supplies Electronic Nicotine Delivery Systems Lung Mice Occupational Health Particulate Matter Safety Smokers Solvents Tobacco Products Vaping

  More +
• Keywords:
  Author Keywords: Adolescent; E-cigarette; Heart Function; Vaping Heart Disease; Electronic Devices; Cigarette Smoking; Biomarkers; Vapors; Particulates; Aerosols; Adolescents; Cardiovascular Disorders;
• Source:
  Circulation 2022 Mar; 145(11):868-870
• ISSN:
  0009-7322
• Pubmed ID:
  35184570
• Pubmed Central ID:
  PMC8923958
• Document Type:
  Text
• Funding:
  R01 AG057046/AG/NIA NIH HHSUnited States/ ; R01 HL139348/HL/NHLBI NIH HHSUnited States/ ; U01 OH012056/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5 pdf pages
• Volume:
  145
• Issue:
  11
• NIOSHTIC Number:
  nn:20065015
• Contact Point Address:
  Loren E. Wold, PhD, FAHA, FAPS, 603 Dorothy M. Davis Heart and Lung Research Institute, Colleges of Medicine and Nursing, Ohio State University, 473 W 12th Avenue, Columbus, OH 43210
• Email:
  loren.wold@osumc.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:524fbe3fb8afe3bc084ba716a320f9a64673ab15aba3bb6ead9b25193d0c76eadd79c673cef40e65447c9f50908a31315d78b05032142dfc9138d534adbd5d04
• Download URL:
  https://stacks.cdc.gov/view/cdc/115494/cdc_115494_DS1.pdf
• File Type:
  [PDF - 664.35 KB ]